Rosmarinic acid

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Cat.No. 0630 - Rosmarinic acid | C18H16O8 | CAS No. 20283-92-5
Description: Anti-inflammatory, cytostatic and antiviral; GPR35 agonist
Chemical Name: [R-(+)]-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-3,4-dihydroxybenzenepropanoic acid
Purity: ≥99% (HPLC)

Biological Activity

Anti-inflammatory, cytostatic and antiviral. Also displays agonist activity at GPR35.

Technical Data

M. Wt 360.32
Formula C18H16O8
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 20283-92-5
PubChem ID 5281792
Smiles O=C(/C=C/C2=CC(O)=C(O)C=C2)O[C@@H](C(O)=O)CC1=CC(O)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 360.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.88 mL 27.75 mL
5 mM 0.56 mL 2.78 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Van Kessel et al (1986) Rosmarinic acid inhibits external oxidative effects of human polymorphonuclear granulocytes. Agents Actions. 17 375 PMID: 3962787

Bult et al (1985) Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br.J.Pharmacol. 84 317 PMID: 3838489

Rampart et al (1986) Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid. Biochem.Pharmacol. 35 1397 PMID: 3516156

Sahu et al (1999) Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b. Biochem.Pharmacol. 57 1439 PMID: 10353266

Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373 PMID: 22523636

If you know of a relevant reference for Rosmarinic acid, please let us know.

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Keywords: Rosmarinic acid, supplier, Anti-inflammatory, cytostatic, anti-viral, Antivirals, GPR35, Antivirals, Tocris Bioscience

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