YE 120

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Description: GPR35 agonist
Chemical Name: 2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile
Purity: ≥98% (HPLC)

Biological Activity for YE 120

YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM).

Compound Libraries for YE 120

YE 120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YE 120

M. Wt 330.17
Formula C16H9Cl2N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 383124-82-1
PubChem ID 12138435
Smiles CC(C(C2=CC=C(Cl)C(Cl)=C2)(C)O1)=C(C#N)/C1=C(C#N)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YE 120

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.02 100

Preparing Stock Solutions for YE 120

The following data is based on the product molecular weight 330.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.29 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References for YE 120

References are publications that support the biological activity of the product.

Deng et al (2011) Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J.Med.Chem. 54 7385 PMID: 21950657

If you know of a relevant reference for YE 120, please let us know.

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Keywords: YE 120, YE 120 supplier, YE120, gpr35, agonists, orphan, receptors, GPR35, 4457, Tocris Bioscience

Citations for YE 120

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