YE 120

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Cat.No. 4457 - YE 120 | C16H9Cl2N3O | CAS No. 383124-82-1
Description: GPR35 agonist
Chemical Name: 2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GPR35 agonist (EC50 = 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM).

Technical Data

M. Wt 330.17
Formula C16H9Cl2N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 383124-82-1
PubChem ID 12138435
InChI Key RSWZFAPYKOARNG-UHFFFAOYSA-N
Smiles CC(C(C2=CC=C(Cl)C(Cl)=C2)(C)O1)=C(C#N)/C1=C(C#N)\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.29 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Deng et al (2011) Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J.Med.Chem. 54 7385 PMID: 21950657


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Literature in this Area

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