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VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 360.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.88 mL||27.76 mL|
|5 mM||0.56 mL||2.78 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References are publications that support the biological activity of the product.
Jalan-Sakrikar et al (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 5 1221 PMID: 25225882
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View all Glutamate (Metabotropic) Group III Receptor Modulators
Keywords: VU 0422288, VU 0422288 supplier, VU0422288, ML396, groupIII, mglu4, mglu8, mglu7, metabotropic, receptors, positive, allosteric, modulators, selective, PAM, ML, 396, Glutamate, (Metabotropic), Group, III, Receptors, 5378, Tocris Bioscience
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