(±)-ADX 71743

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Description: Negative allosteric modulator of mGlu7 receptors; brain penetrant
Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Purity: ≥98% (HPLC)
Citations (1)
Literature (4)

Biological Activity for (±)-ADX 71743

(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Compound Libraries for (±)-ADX 71743

(±)-ADX 71743 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-ADX 71743

M. Wt 269.34
Formula C17H19NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 53391766
Smiles CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-ADX 71743

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.93 100
ethanol 26.93 100

Preparing Stock Solutions for (±)-ADX 71743

The following data is based on the product molecular weight 269.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.56 mL 37.13 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for (±)-ADX 71743

Certificate of Analysis / Product Datasheet
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References for (±)-ADX 71743

References are publications that support the biological activity of the product.

Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600 PMID: 25972184

Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31 PMID: 27199672

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Keywords: (±)-ADX 71743, (±)-ADX 71743 supplier, (±)-ADX, 71743, potent, negative, allosteric, modulators, NAMs, mGlu7, receptors, metabotropic, glutamate, epilepsy, 1431641-29-0, Glutamate, (Metabotropic), Group, III, Receptors, 5715, Tocris Bioscience

1 Citation for (±)-ADX 71743

Citations are publications that use Tocris products. Selected citations for (±)-ADX 71743 include:

Harold D et al (2022) Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Mol Biol Cell 33 ar66 PMID: 35511883

Do you know of a great paper that uses (±)-ADX 71743 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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