AMN 082 dihydrochloride

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Description: Selective mGlu7 agonist
Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (4)

Biological Activity for AMN 082 dihydrochloride

AMN 082 dihydrochloride is a the first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

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Compound Libraries for AMN 082 dihydrochloride

AMN 082 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AMN 082 dihydrochloride

M. Wt 465.45
Formula C28H28N2.2HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 97075-46-2
PubChem ID 11698390
InChI Key YRQCDCNQANSUPB-UHFFFAOYSA-N
Smiles Cl.Cl.C(CNC(C1=CC=CC=C1)C1=CC=CC=C1)NC(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMN 082 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100
water 0.93 2 with gentle warming

Preparing Stock Solutions for AMN 082 dihydrochloride

The following data is based on the product molecular weight 465.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets for AMN 082 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for AMN 082 dihydrochloride

References are publications that support the biological activity of the product.

Greco et al (2010) Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 332 1064 PMID: 19940105

Flor et al (2005) AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo. Neuropharmacology 49 244

Mitsukawa et al (2005) A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc.Natl.Acad.Sci.USA 102 18712


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Keywords: AMN 082 dihydrochloride, AMN 082 dihydrochloride supplier, selective, mGlu7, mGluR7, agonists, mGlur, Group, III, Receptors, Glutamate, Metabotropic, AMN082, dihydrochloride, (Metabotropic), 2385, Tocris Bioscience

3 Citations for AMN 082 dihydrochloride

Citations are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:

Shao et al (2019) Activating metabotropic glutamate receptor-7 attenuates visceral hypersensitivity in neonatal maternally separated rats. Int J Mol Med 43 761 PMID: 30569115

Broadstock et al (2012) Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol 165 1034 PMID: 21627638

Jantas et al (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology 141 223 PMID: 30170084


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Reviews for AMN 082 dihydrochloride

Average Rating: 4 (Based on 1 Review.)

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Test of potential modulation of 5HT-1B receptor effects.
By Sergiy Sylantyev on 12/10/2023
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Arcuate nucleus

AMN 082 was used to test a (potential) impact of metabotropic glutamate receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of metabotropic glutamate receptors (with 1 μM CHPG, 1 μM (RS)-3,5-DHPG and 1 μM AMN 082), GABA-B receptors and ACh receptors does not show a significant effect. Grey traces: individual recordings; red: averaged trace.

PMID: 37827445
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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