MSOP

Pricing Availability Delivery Time Qty
Cat.No. 0803 - MSOP | C4H10NO6P | CAS No. 66515-29-5
Description: Specific group III mGlu antagonist
Chemical Name: (RS)-α-Methylserine-O-phosphate
Datasheet
Citations (5)
Literature

Biological Activity

Selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M. Wt 199.1
Formula C4H10NO6P
Storage Store at RT
CAS Number 66515-29-5
PubChem ID 3964633
InChI Key GSFCOAGADOGIGE-UHFFFAOYSA-N
Smiles NC(COP(O)(O)=O)(C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 199.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.02 mL 25.11 mL 50.23 mL
5 mM 1 mL 5.02 mL 10.05 mL
10 mM 0.5 mL 2.51 mL 5.02 mL
50 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Thomas et al (1996) α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 35 637 PMID: 8887973

Jane et al (1996) Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon 109-110 313 PMID:

Thomas et al (1995) Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr. 21 P616 PMID:


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Keywords: MSOP, supplier, Specific, group, III, mGlur, antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

5 Citations for MSOP

Citations are publications that use Tocris products. Selected citations for MSOP include:

Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. J Neurosci 108 9993 PMID: 21628565

Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Physiol 26 9666 PMID: 16988037

Browning et al (2006) Vagal afferent control of opioidergic effects in rat brainstem circuits. Biomed Res Int 575 761 PMID: 16825311

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923

Spaziano et al (2015) Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Proc Natl Acad Sci U S A 2015 980983 PMID: 25866824


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