XAP 044

Pricing Availability Delivery Time Qty
Cat.No. 5248 - XAP 044 | C15H9IO4 | CAS No. 196928-50-4
Description: Potent and selective mGlu7 antagonist
Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

Technical Data

M. Wt 380.13
Formula C15H9IO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 196928-50-4
PubChem ID 5428913
InChI Key XXZKJJYWINSUMJ-UHFFFAOYSA-N
Smiles OC1=CC=C(C(C(OC3=CC=C(I)C=C3)=CO2)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.01 100
ethanol 7.6 20

Preparing Stock Solutions

The following data is based on the product molecular weight 380.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.31 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975 PMID: 24596089


If you know of a relevant reference for XAP 044, please let us know.

Keywords: XAP044 potent specific mGlu7 antagonists glutamate metabotropic group III receptors venus flytrap domain VFTD anti-anxiety Brain penetrant Glutamate (Metabotropic) Group III Receptors

Citations for XAP 044

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Pathways for XAP 044

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