Glutamate (Metabotropic) Group I Receptor Modulators

Cat. No. Product Name / Activity
4416 ADX 10059 hydrochloride
Negative allosteric modulator of mGlu5 receptors
3235 CDPPB
Positive allosteric modulator of mGlu5 receptors
4787 CPPHA
Positive allosteric modulator of mGlu1 and mGlu5 receptors
1952 DCB
Allosteric modulator of mGlu5 receptors
1625 DFB
Positive allosteric modulator of mGlu5 receptors
1953 DMeOB
Negative allosteric modulator of mGlu5 receptors
2386 Fenobam
Potent and selective mGlu5 negative allosteric modulator (NAM)
6859 FITM
Potent and selective negative allosteric modulator of mGlu1 receptors
5000 FTIDC
Potent and selective negative allosteric modulator of mGlu1 receptors; also mGlu1 inverse agonist
5275 LSN 2463359
Potent and selective positive allosteric modulator of mGlu5 receptors
4438 MFZ 10-7
Negative allosteric modulator of mGlu5 receptors
4348 Ro 01-6128
Positive allosteric modulator of mGlu1 receptors
4347 Ro 67-4853
Positive allosteric modulator of group I mGlu receptors
4346 Ro 67-7476
Positive allosteric modulator of mGlu1 receptors
4381 VU 0285683
Negative allosteric modulator of mGlu5 receptors
4437 VU 0357121
Positive allosteric modulator of mGlu5 receptors
4323 VU 0360172 hydrochloride
Positive allosteric modulator of mGlu5 receptors
4394 VU 0360223
Negative allosteric modulator of mGlu5 receptors
5322 VU 0409106
Potent and selective negative allosteric modulator of mGlu5 receptors
5693 VU 0409551
Selective positive allosteric modulator of mGlu5 receptors; brain penetrant and orally bioavailable
6895 VU 0424465
Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity
5379 VU 0469650 hydrochloride
Potent and selective negative allosteric modulator of mGlu1 receptors
5377 VU 0483605
Positive allosteric modulator of mGlu1 receptors
3325 VU 1545
Positive allosteric modulator of mGlu5 receptors
4458 VU 29
Potent positive allosteric modulator of mGlu5 receptors