ADX 10059 hydrochloride
Reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 276.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.61 mL||18.07 mL||36.14 mL|
|5 mM||0.72 mL||3.61 mL||7.23 mL|
|10 mM||0.36 mL||1.81 mL||3.61 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891 PMID: 21757343
Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192 PMID: 19460767
Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555 PMID: 20218930
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Keywords: ADX 10059 hydrochloride, supplier, metabotropics, glutamate, receptor, 5, mglur5, mglu5, NAMs, negative, allosteric, modulators, ADX10059, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
Citations for ADX 10059 hydrochloride
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