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Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Displays no activity at human mGlu1 receptors.
Ro 67-7476 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 319.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.13 mL||15.65 mL||31.31 mL|
|5 mM||0.63 mL||3.13 mL||6.26 mL|
|10 mM||0.31 mL||1.57 mL||3.13 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References are publications that support the biological activity of the product.
Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402 PMID: 11606768
If you know of a relevant reference for Ro 67-7476, please let us know.
View all Glutamate (Metabotropic) Group I Receptor Modulators
Keywords: Ro 67-7476, Ro 67-7476 supplier, Ro67-7476, mglur1a, positive, allosteric, modulators, pams, Glutamate, (Metabotropic), Group, I, Receptors, 4346, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Ro 67-7476 include:
Bariselli et al (2016) SHANK3 controls maturation of social reward circuits in the VTA. Nat Neurosci 19 926 PMID: 27273769
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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