Ro 67-4853

Pricing Availability   Qty
Description: Positive allosteric modulator of group I mGlu receptors
Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for Ro 67-4853

Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).

Technical Data for Ro 67-4853

M. Wt 325.36
Formula C19H19NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 302841-89-0
PubChem ID 9949202
InChI Key RQBUXEUMZZQUFY-UHFFFAOYSA-N
Smiles O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 67-4853

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.54 100

Preparing Stock Solutions for Ro 67-4853

The following data is based on the product molecular weight 325.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.37 mL 30.74 mL
5 mM 0.61 mL 3.07 mL 6.15 mL
10 mM 0.31 mL 1.54 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References for Ro 67-4853

References are publications that support the biological activity of the product.

Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402 PMID: 11606768

Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124


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Citations for Ro 67-4853

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Reviews for Ro 67-4853

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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