VU 0360172 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4323 - VU 0360172 hydrochloride | C18H15FN2O.HCl | CAS No. 1309976-62-2
Description: Positive allosteric modulator at mGlu5
Chemical Name: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Compound Libraries

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Technical Data

M. Wt 330.78
Formula C18H15FN2O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1309976-62-2
PubChem ID 53384852
InChI Key NBGAPTWZQXSEAA-UHFFFAOYSA-N
Smiles FC1=CC=CC(C#CC2=CC=C(C(NC3CCC3)=O)C=N2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.54 50
ethanol 8.27 25

Preparing Stock Solutions

The following data is based on the product molecular weight 330.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.12 mL 30.23 mL
5 mM 0.6 mL 3.02 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rodriguez et al (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 1105 PMID: 20923853

D'Amore et al (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology 66 330 PMID: 22705340


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Keywords: VU0360172 Positive allosteric modulators mGlu5 mGluR5 mGlur Group I Receptors Glutamate Metabotropic antipsychotic absence epilepsy Glutamate (Metabotropic) Group I Receptors

Citations for VU 0360172 hydrochloride

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