The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.
Inhibitors |
Cat. No. | Product Name / Activity |
---|---|
5318 | AEE 788 |
Potent EGFR and VEGFR inhibitor | |
6812 | Afatinib dimaleate |
Potent dual specificity EGFR/HER2 inhibitor; active in vivo | |
1276 | AG 1478 hydrochloride |
Highly potent EGFR-kinase inhibitor | |
0493 | AG 18 |
EGFR/PDGFR-kinase inhibitor | |
0414 | AG 490 |
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor | |
0619 | AG 494 |
Potent EGFR-kinase inhibitor | |
0618 | AG 555 |
Potent EGFR-kinase inhibitor | |
1555 | AG 825 |
Selective ErbB2 inhibitor | |
2617 | AG 879 |
ErbB2 inhibitor | |
0497 | AG 99 |
EGFR-kinase inhibitor | |
4397 | AV 412 |
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases | |
2417 | BIBU 1361 dihydrochloride |
Selective inhibitor of EGFR-kinase | |
2416 | BIBX 1382 dihydrochloride |
Highly selective EGFR-kinase inhibitor | |
5022 | BMS 599626 dihydrochloride |
Potent, selective EGFR and ErbB2 inhibitor | |
5916 | Canertinib dihydrochloride |
Potent EGFR kinase inhibitor | |
3360 | CGP 52411 |
EGFR inhibitor. Also inhibits Aβ42 fibril formation | |
5973 | CP 724714 |
Potent and selective ErbB2 inhibitor | |
6231 | Dacomitinib |
Potent irreversible pan ErbB inhibitor | |
4502 | DIM |
Inhibits EGFR activation; also induces apoptosis | |
1110 | Genistein |
EGFR kinase inhibitor. Also estrogen and PPARγ ligand | |
2239 | GW 583340 dihydrochloride |
Potent dual EGFR/ErbB2 inhibitor; orally active | |
3580 | HKI 357 |
Dual irreversible inhibitor of ErbB2 and EGFR | |
3000 | Iressa |
Orally active, selective EGFR inhibitor | |
6962 | JBJ-03-142-02 |
Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors | |
3352 | JNJ 28871063 hydrochloride |
Potent ErbB receptor family inhibitor | |
6811 | Lapatinib |
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | |
1331 | Lavendustin A |
EGFR, p60c-src inhibitor | |
0577 | Methyl 2,5-dihydroxycinnamate |
EGFR-kinase inhibitor | |
1037 | PD 153035 hydrochloride |
EGFR-kinase inhibitor | |
2615 | PD 158780 |
Potent ErbB receptor family inhibitor | |
6349 | Pelitinib |
Potent and irreversible EGFR inhibitor; orally bioavailable | |
5939 | PF 6274484 |
High affinity and potent covalent EGFR kinase inhibitor | |
4941 | PKI 166 hydrochloride |
Potent EGFR-kinase inhibitor | |
2794 | PP 3 |
EGFR-kinase inhibitor. Also Src kinase negative control | |
3599 | TAK 165 |
Potent and selective ErbB2 inhibitor | |
0579 | Tyrphostin B44, (+) enantiomer |
EGFR-kinase inhibitor | |
3115 | WHI-P 154 |
Potent EGFR inhibitor. Also inhibits JAK3 | |
Degraders |
Cat. No. | Product Name / Activity |
7258 | Gefitinib-based PROTAC® 3 New |
Potent EGFR Degrader | |
7261 | SJF 1521 New |
Selective EGFR Degrader | |
7262 | SJF 1528 New |
Potent EGFR Degrader; also degrades HER2 | |
Other |
Cat. No. | Product Name / Activity |
6556 | Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate |
High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646 | |
6557 | Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate |
Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate |
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified: EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/heterodimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, decreased apoptosis and increased cell proliferation.
Tocris offers the following scientific literature for EGFR to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
EGFR | Human | EGFR | NM_005228 | P00533 |
Mouse | Egfr | NM_207655 | Q01279 | |
Rat | Egfr | NM_031507 | Q62954 | |
ErbB2 | Human | ERBB2 | NM_001005862 | P04626 |
Mouse | Erbb2 | NM_001003817 | P70424 | |
Rat | Erbb2 | NM_017003 | P06494 | |
ErbB3 | Human | ERBB3 | NM_001005915 | P21860 |
Mouse | Erbb3 | NM_010153 | Q61526 | |
Rat | Erbb3 | NM_017218 | Q62799 | |
ErbB4 | Human | ERBB4 | NM_001042599 | Q15303 |
Mouse | Erbb4 | NM_010154 | Q61527 | |
Rat | Erbb4 | NM_021687 | Q62956 |