EGFR

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5318 AEE 788
Potent EGFR and VEGFR inhibitor
1276 AG 1478 hydrochloride
Highly potent EGFR-kinase inhibitor
0493 AG 18
EGFR/PDGFR-kinase inhibitor
0414 AG 490
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
0619 AG 494
Potent EGFR-kinase inhibitor
0618 AG 555
Potent EGFR-kinase inhibitor
0616 AG 556
EGFR-kinase inhibitor
1555 AG 825
Selective ErbB2 inhibitor
2617 AG 879
ErbB2 inhibitor
0497 AG 99
EGFR-kinase inhibitor
4397 AV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases
2417 BIBU 1361 dihydrochloride
Selective inhibitor of EGFR-kinase
2416 BIBX 1382 dihydrochloride
Highly selective EGFR-kinase inhibitor
5022 BMS 599626 dihydrochloride
Potent, selective EGFR and ErbB2 inhibitor
5916 Canertinib dihydrochloride
Potent EGFR kinase inhibitor
3360 CGP 52411
EGFR inhibitor. Also inhibits Aβ42 fibril formation
5973 CP 724714
Potent and selective ErbB2 inhibitor
6231 Dacomitinib
Potent irreversible pan ErbB inhibitor
4502 DIM
Inhibits EGFR activation; also induces apoptosis
1110 Genistein
EGFR kinase inhibitor. Also estrogen and PPARγ ligand
2239 GW 583340 dihydrochloride
Potent dual EGFR/ErbB2 inhibitor; orally active
2646 HDS 029
Potent inhibitor of the ErbB receptor family
3580 HKI 357
Dual irreversible inhibitor of ErbB2 and EGFR
3000 Iressa
Orally active, selective EGFR inhibitor
3352 JNJ 28871063 hydrochloride
Potent ErbB receptor family inhibitor
1331 Lavendustin A
EGFR, p60c-src inhibitor
0577 Methyl 2,5-dihydroxycinnamate
EGFR-kinase inhibitor
1037 PD 153035 hydrochloride
EGFR-kinase inhibitor
2615 PD 158780
Potent ErbB receptor family inhibitor
5939 PF 6274484
High affinity and potent covalent EGFR kinase inhibitor
4941 PKI 166 hydrochloride
Potent EGFR-kinase inhibitor
2794 PP 3
EGFR-kinase inhibitor. Also Src kinase negative control
3599 TAK 165
Potent and selective ErbB2 inhibitor
0578 Tyrphostin B44, (-) enantiomer
EGFR-kinase inhibitor
0579 Tyrphostin B44, (+) enantiomer
EGFR-kinase inhibitor
3115 WHI-P 154
Potent EGFR inhibitor. Also inhibits JAK3

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified: EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).

EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/heterodimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, decreased apoptosis and increased cell proliferation.

External sources of pharmacological information for EGFR :

    Literature for EGFR

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Angiogenesis in Cancer

    Angiogenesis in Cancer Poster

    Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

    Schizophrenia

    Schizophrenia Poster

    Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

    EGF Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    EGFR Human EGFR NM_005228 P00533
    Mouse Egfr NM_207655 Q01279
    Rat Egfr NM_031507 Q62954
    ErbB2 Human ERBB2 NM_001005862 P04626
    Mouse Erbb2 NM_001003817 P70424
    Rat Erbb2 NM_017003 P06494
    ErbB3 Human ERBB3 NM_001005915 P21860
    Mouse Erbb3 NM_010153 Q61526
    Rat Erbb3 NM_017218 Q62799
    ErbB4 Human ERBB4 NM_001042599 Q15303
    Mouse Erbb4 NM_010154 Q61527
    Rat Erbb4 NM_021687 Q62956