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WZ 4002 New
Biological Activity for WZ 4002
WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.
Sold under license from Dana-Farber Cancer Institute.
Technical Data for WZ 4002
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WZ 4002
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for WZ 4002
The following data is based on the product molecular weight 494.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.2 mL||101.01 mL||202.03 mL|
|0.5 mM||4.04 mL||20.2 mL||40.41 mL|
|1 mM||2.02 mL||10.1 mL||20.2 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
References for WZ 4002
References are publications that support the biological activity of the product.
Zhou et al (2009) Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462 1070 PMID: 20033049
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Keywords: WZ 4002, WZ 4002 supplier, WZ4002, potent, EGFR, epidermal, growth, factor, receptor, tyrosine, kinase, inhibitors, inhibits, mutant-selective, T790M, L858R, 6290, Tocris Bioscience
Citations for WZ 4002
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.