Erlotinib Hydrochloride

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Cat.No. 7194 - Erlotinib Hydrochloride | C22H23N3O4.HCl | CAS No. 183319-69-9
Description: Potent, reversible EGFR tyrosine kinase inhibitor
Chemical Name: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Erlotinib Hydrochloride

Erlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC50 = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC50 values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.

Technical Data for Erlotinib Hydrochloride

M. Wt 429.9
Formula C22H23N3O4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 183319-69-9
PubChem ID 176871
InChI Key GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Smiles Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Erlotinib Hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.6 20

Preparing Stock Solutions for Erlotinib Hydrochloride

The following data is based on the product molecular weight 429.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.63 mL 58.15 mL 116.31 mL
1 mM 2.33 mL 11.63 mL 23.26 mL
2 mM 1.16 mL 5.82 mL 11.63 mL
10 mM 0.23 mL 1.16 mL 2.33 mL

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Product Datasheets for Erlotinib Hydrochloride

References for Erlotinib Hydrochloride

References are publications that support the biological activity of the product.

Santos et al (2019) Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 10 PMID: 31562298

Moyer et al (1997) Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57 4838 PMID: 9354447


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Citations for Erlotinib Hydrochloride

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