Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewErlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC50 = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC50 values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.
Erlotinib Hydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
M. Wt | 429.9 |
Formula | C22H23N3O4.HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 183319-69-9 |
PubChem ID | 176871 |
InChI Key | GTTBEUCJPZQMDZ-UHFFFAOYSA-N |
Smiles | Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.6 | 20 |
The following data is based on the product molecular weight 429.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 11.63 mL | 58.15 mL | 116.31 mL |
1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
2 mM | 1.16 mL | 5.82 mL | 11.63 mL |
10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
References are publications that support the biological activity of the product.
Santos et al (2019) Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 10 PMID: 31562298
Moyer et al (1997) Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57 4838 PMID: 9354447
If you know of a relevant reference for Erlotinib Hydrochloride, please let us know.
Keywords: Erlotinib Hydrochloride, Erlotinib Hydrochloride supplier, erlotinib, HCl, hydrochloride, potent, reversible, EGFR, tyrosine, kinase, inhibitors, inhibits, epidermal, growth, factor, receptor, antiproliferative, organoids, differentiation, Organoids, 7194, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Erlotinib Hydrochloride. Do you know of a great paper that uses Erlotinib Hydrochloride from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Erlotinib Hydrochloride and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.