Home / Pharmacology / Enzyme-Linked Receptors / Receptor Tyrosine Kinases (RTKs) / EGFR / EGFR Inhibitors / JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride

Cat. No. 3352 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent ErbB receptor family inhibitor
Chemical Name: 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Compound Libraries for JNJ 28871063 hydrochloride

JNJ 28871063 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 28871063 hydrochloride

M. Wt 519.42
Formula C24H27ClN6O3.HCl
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 944342-90-9
PubChem ID 17747413
InChI Key ZXKZRKQMKNRZNN-GZPZNDDGSA-N
Smiles NC1=C(/C=N/OCCN2CCOCC2)C(NC3=CC(Cl)=C(OCC4=CC=CC=C4)C=C3)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ 28871063 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.97 50

Preparing Stock Solutions for JNJ 28871063 hydrochloride

The following data is based on the product molecular weight 519.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.85 mL 19.25 mL 38.5 mL
2.5 mM 0.77 mL 3.85 mL 7.7 mL
5 mM 0.39 mL 1.93 mL 3.85 mL
25 mM 0.08 mL 0.39 mL 0.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for JNJ 28871063 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for JNJ 28871063 hydrochloride

References are publications that support the biological activity of the product.

Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271 PMID: 17981994

Emanuel et al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338 PMID: 17975007

Guessous et al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217 577 PMID: 18651559

If you know of a relevant reference for JNJ 28871063 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all EGFR Inhibitors

Keywords: JNJ 28871063 hydrochloride, JNJ 28871063 hydrochloride supplier, Potent, ErbB, receptor, family, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, JNJ28871063, hydrochloride, 3352, Tocris Bioscience

Citations for JNJ 28871063 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for JNJ 28871063 hydrochloride. Do you know of a great paper that uses JNJ 28871063 hydrochloride from Tocris? Please let us know.

Reviews for JNJ 28871063 hydrochloride

There are currently no reviews for this product. Be the first to review JNJ 28871063 hydrochloride and earn rewards!

Have you used JNJ 28871063 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.