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Biological Activity for Tucatinib
Tucatinib is a potent and selective ErbB-2 (also called HER2) kinase inhibitor (IC50 = 7 nM). It exhibits >50-fold selectivity for ErbB-2 over EGFR. In vitro, Tucatinib inhibits ErbB-2 signaling activity and cell proliferation in ErbB-2-amplified breast cancer cell lines (BT-474). In vivo, Tucatinib (25-100 mg/kg) reduces tumor volume in breast and gastric xenograft mouse models.This compound is orally bioavailable.
Technical Data for Tucatinib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tucatinib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Tucatinib
The following data is based on the product molecular weight 480.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.08 mL||10.41 mL||20.81 mL|
|5 mM||0.42 mL||2.08 mL||4.16 mL|
|10 mM||0.21 mL||1.04 mL||2.08 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References for Tucatinib
References are publications that support the biological activity of the product.
Kulukian et al (2020) Preclinical activity of HER2-selective Tyrosine Kinase inhibitor Tucatinib as a single agent or in combination with Trastuzumab or Docetaxel in solid tumor models. Mol.Cancer.Ther. 19 976 PMID: 32241871
If you know of a relevant reference for Tucatinib, please let us know.
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Citations for Tucatinib
Citations are publications that use Tocris products.
Currently there are no citations for Tucatinib. Do you know of a great paper that uses Tucatinib from Tocris? Please let us know.
Reviews for Tucatinib
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.