MS 154N

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Description: Negative control for MS 154 (Cat No. 7395)
Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for MS 154N

MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 154N

M. Wt 915.46
Formula C47H56ClFN8O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2675490-97-6
PubChem ID 155515813

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MS 154N

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 91.55 100

Preparing Stock Solutions for MS 154N

The following data is based on the product molecular weight 915.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.22 mL 1.09 mL 2.18 mL
10 mM 0.11 mL 0.55 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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References for MS 154N

References are publications that support the biological activity of the product.

Cheng et al (2020) Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 63 1216 PMID: 31895569

If you know of a relevant reference for MS 154N, please let us know.

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Citations for MS 154N

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia