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Biological Activity for MS 154N
MS 154N is a negative control for MS 154 (Cat No. 7395). The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kd values are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.
Sold under license from Icahn School of Medicine at Mount Sinai.
Technical Data for MS 154N
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MS 154N
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MS 154N
The following data is based on the product molecular weight 915.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.09 mL||5.46 mL||10.92 mL|
|5 mM||0.22 mL||1.09 mL||2.18 mL|
|10 mM||0.11 mL||0.55 mL||1.09 mL|
|50 mM||0.02 mL||0.11 mL||0.22 mL|
References for MS 154N
References are publications that support the biological activity of the product.
Cheng et al (2020) Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 63 1216 PMID: 31895569
If you know of a relevant reference for MS 154N, please let us know.
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Citations for MS 154N
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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