Cathepsin

Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z).

Products
Background
Literature (1)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
0384 N-Acetyl-L-leucyl-L-leucyl-L-methional
Cathepsin inhibitor
5585 Balicatib
Potent and selective cathepsin K inhibitor
4863 CA 074
Selective cathepsin B inhibitor
0448 Calpeptin
Calpain and cathepsin L inhibitor
5208 E 64
Potent and irreversible cysteine protease inhibitor
4545 E 64d
Cathepsin inhibitor; interferes with autolysosomal digestion
3066 L 006235
Potent cathepsin K inhibitor
1146 MDL 28170
Potent, selective calpain and cathepsin B inhibitor
3625 SID 26681509
Cathepsin L inhibitor

Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z).

Most cathepsins are endopeptidases, with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH.

The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes, including maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, rheumatoid arthritis, osteoarthritis and atherosclerosis.

External sources of pharmacological information for Cathepsin :

    Literature for Cathepsin

    Tocris offers the following scientific literature for Cathepsin to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    New Product Guide

    New Product Guide [Spring/Summer 2019]

    Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

    • 7-TM Receptors
    • Enzymes
    • Enzyme-Linked Receptors
    • Ion Channels
    • Nuclear Receptors
    • Transporters
    • Chemogenetics
    • Epigenetics
    • Fluorescent Imaging
    • PROTACs
    • Signal Transduction
    • Stem Cells

    Cathepsin Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Serine Proteases
    Cathepsin A Human CTSA NM_000308 P10619
    Mouse Ctsa NM_008906 P16675
    Cathepsin G Human CTSG NM_001911 P08311
    Mouse Ctsg NM_007800 P28293
    Rat Ctsg NM_001106041 P17977
    Aspartic Proteases
    Cathepsin D Human CTSD NM_001909 P07339
    Mouse Ctsd NM_009983 P18242
    Rat Ctsd NM_134334 Q6P6T6
    Cathepsin E Human CTSE NM_001910 P14091
    Mouse Ctse NM_007799 P70269
    Rat Ctse NM_012938 P16228
    Cysteine Proteases
    Cathepsin B Human CTSB NM_147780 P07858
    Mouse Ctsb NM_007798 P10605
    Rat Ctsb NM_012838 P01041
    Cathepsin C Human CTSC NM_001814 Q8WYA8
    Mouse Ctsc NM_009982 P97821
    Rat Ctsc NM_017097 P80067
    Cathepsin F Human CTSF NM_003793 Q9UBX1
    Mouse Ctsf NM_019861 Q9R013
    Rat Ctsf NM_001034110 Q499S6
    Cathepsin H Human CTSH NM_004390 P09668
    Mouse Ctsh NM_007801 P49935
    Rat Ctsh NM_012939 P00786
    Cathepsin K Human CTSK NM_000396 P43235
    Mouse Ctsk NM_007802 P55097
    Rat Ctsk NM_031560 O35186
    Cathepsin L1 Human CTSL1 NM_001912 P07711
    Mouse Ctsl NM_009984 P06797
    Rat Ctsl1 NM_013156 P07154
    Cathepsin L2 Human CTSL2 NM_001333 O60911
    Cathepsin L3 Human CTSL3 NM_001023564 Q5NE16
    Cathepsin O Human CTSO NM_001334 P43234
    Mouse Ctso NM_177662 Q8BM88
    Cathepsin S Human CTSS NM_004079 P25774
    Mouse Ctss NM_021281 O70370
    Rat Ctss NM_017320 Q02765
    Cathepsin W Human CTSW NM_001335 P56202
    Mouse Ctsw NM_009985 P56203
    Rat Ctsw NM_001024242 Q561Q9
    Cathepsin Z Human CTSZ NM_001336 Q9UBR2
    Mouse Ctsz NM_022325 Q9WUU7
    Rat Ctsz NM_183330 Q9R1T3