Cathepsin

Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
0384 N-Acetyl-L-leucyl-L-leucyl-L-methional
Cathepsin inhibitor
5585 Balicatib
Potent and selective cathepsin K inhibitor
4863 CA 074
Selective cathepsin B inhibitor
0448 Calpeptin
Calpain and cathepsin L inhibitor
5208 E 64
Potent and irreversible cysteine protease inhibitor
4545 E 64d
Cathepsin inhibitor; interferes with autolysosomal digestion
3066 L 006235
Potent cathepsin K inhibitor
1146 MDL 28170
Potent, selective calpain and cathepsin B inhibitor
3625 SID 26681509
Cathepsin L inhibitor

Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z).

Most cathepsins are endopeptidases, with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH.

The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes, including maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, rheumatoid arthritis, osteoarthritis and atherosclerosis.

Literature for Cathepsin

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Cathepsin Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Serine Proteases
Cathepsin A Human CTSA NM_000308 P10619
Mouse Ctsa NM_008906 P16675
Cathepsin G Human CTSG NM_001911 P08311
Mouse Ctsg NM_007800 P28293
Rat Ctsg NM_001106041 P17977
Aspartic Proteases
Cathepsin D Human CTSD NM_001909 P07339
Mouse Ctsd NM_009983 P18242
Rat Ctsd NM_134334 Q6P6T6
Cathepsin E Human CTSE NM_001910 P14091
Mouse Ctse NM_007799 P70269
Rat Ctse NM_012938 P16228
Cysteine Proteases
Cathepsin B Human CTSB NM_147780 P07858
Mouse Ctsb NM_007798 P10605
Rat Ctsb NM_012838 P01041
Cathepsin C Human CTSC NM_001814 Q8WYA8
Mouse Ctsc NM_009982 P97821
Rat Ctsc NM_017097 P80067
Cathepsin F Human CTSF NM_003793 Q9UBX1
Mouse Ctsf NM_019861 Q9R013
Rat Ctsf NM_001034110 Q499S6
Cathepsin H Human CTSH NM_004390 P09668
Mouse Ctsh NM_007801 P49935
Rat Ctsh NM_012939 P00786
Cathepsin K Human CTSK NM_000396 P43235
Mouse Ctsk NM_007802 P55097
Rat Ctsk NM_031560 O35186
Cathepsin L1 Human CTSL1 NM_001912 P07711
Mouse Ctsl NM_009984 P06797
Rat Ctsl1 NM_013156 P07154
Cathepsin L2 Human CTSL2 NM_001333 O60911
Cathepsin L3 Human CTSL3 NM_001023564 Q5NE16
Cathepsin O Human CTSO NM_001334 P43234
Mouse Ctso NM_177662 Q8BM88
Cathepsin S Human CTSS NM_004079 P25774
Mouse Ctss NM_021281 O70370
Rat Ctss NM_017320 Q02765
Cathepsin W Human CTSW NM_001335 P56202
Mouse Ctsw NM_009985 P56203
Rat Ctsw NM_001024242 Q561Q9
Cathepsin Z Human CTSZ NM_001336 Q9UBR2
Mouse Ctsz NM_022325 Q9WUU7
Rat Ctsz NM_183330 Q9R1T3