SID 26681509

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Cat.No. 3625 - SID 26681509 | C27H33N5O5S | CAS No. 958772-66-2
Description: Cathepsin L inhibitor
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

Technical Data

M. Wt 539.65
Formula C27H33N5O5S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 958772-66-2
PubChem ID 16725315
InChI Key OTIWAYTTYNFEKL-QFIPXVFZSA-N
Smiles O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.98 50
ethanol 5.4 10

Preparing Stock Solutions

The following data is based on the product molecular weight 539.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.71 mL 18.53 mL 37.06 mL
2.5 mM 0.74 mL 3.71 mL 7.41 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
25 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34 PMID: 18403718

Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210 PMID: 18060772


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Literature in this Area

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