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Biological Activity for SID 26681509
SID 26681509 is a potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.
Compound Libraries for SID 26681509
Technical Data for SID 26681509
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SID 26681509
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SID 26681509
The following data is based on the product molecular weight 539.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.71 mL||18.53 mL||37.06 mL|
|2.5 mM||0.74 mL||3.71 mL||7.41 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|25 mM||0.07 mL||0.37 mL||0.74 mL|
References for SID 26681509
References are publications that support the biological activity of the product.
Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34 PMID: 18403718
Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210 PMID: 18060772
If you know of a relevant reference for SID 26681509, please let us know.
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Keywords: SID 26681509, SID 26681509 supplier, SID26681509, cathepsin, L, inhibitors, inhibits, cysteine, protease, antimalarial, Cathepsin, Calcium-Sensitive, Proteases, 3625, Tocris Bioscience
1 Citation for SID 26681509
Citations are publications that use Tocris products. Selected citations for SID 26681509 include:
Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839
Do you know of a great paper that uses SID 26681509 from Tocris? Please let us know.
Reviews for SID 26681509
Average Rating: 5 (Based on 1 Review.)
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