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Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 539.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.71 mL||18.53 mL||37.06 mL|
|2.5 mM||0.74 mL||3.71 mL||7.41 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|25 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Shah et al (2008) Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 74 34 PMID: 18403718
Myers et al (2008) Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 18 210 PMID: 18060772
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Keywords: SID 26681509, SID 26681509 supplier, SID26681509, cathepsin, L, inhibitors, inhibits, cysteine, protease, antimalarial, Cathepsin, Calcium-Sensitive, Proteases, 3625, Tocris Bioscience
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