Calcium-Sensitive Protease Modulators

Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. Cathepsins are lysosomal calcium-sensitive proteases that have a key role in cellular protein turnover.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
0384 N-Acetyl-L-leucyl-L-leucyl-L-methional
Cathepsin inhibitor
4863 CA 074
Selective cathepsin B inhibitor
2950 Acetyl-Calpastatin (184-210) (human)
Selective calpain inhibitor
0448 Calpeptin
Calpain and cathepsin L inhibitor
5208 E 64
Potent and irreversible cysteine protease inhibitor
4545 E 64d
Cathepsin inhibitor; interferes with autolysosomal digestion
3066 L 006235
Potent cathepsin K inhibitor
1146 MDL 28170
Potent, selective calpain and cathepsin B inhibitor
3358 MG 101
Calpain inhibitor; activates p53-dependent apoptosis
1748 MG 132
Calpain and proteasome inhibitor
1269 PD 150606
Cell permeable calpain inhibitor
3625 SID 26681509
Cathepsin L inhibitor

Related Targets

Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. These include remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation.

Cathepsins are lysosomal calcium-sensitive proteases that have a key role in cellular protein turnover. This group of proteases includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) and cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes. These include maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, osteo- and rheumatoid arthritis, and atherosclerosis.

Calcium Sensitive Protease Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Calpains
Calpain 1 Human CAPN1 NM_005186 P07384
Mouse Capn1 NM_007600 O35350
Rat Capn1 NM_019152 P97571
Calpain 2 Human CAPN2 NM_001748 P17655
Mouse Capn2 NM_009794 O08529
Rat Capn2 NM_017116 Q07009
Calpain 3 Human CAPN3 NM_000070 P20807
Mouse Capn3 NM_007601 Q64691
Rat Capn3 NM_017117 Q9R113
Calpain 5 Human CAPN5 NM_004055 O15484
Mouse Capn5 NM_007602 O08688
Rat Capn5 NM_134461 Q8R4C0
Calpain 6 Human CAPN6 NM_014289 Q9Y6Q1
Mouse Capn6 NM_007603 O35646
Rat Capn6 NM_031808 O88501
Calpain 7 Human CAPN7 NM_014296 Q9Y6W3
Mouse Capn7 NM_009796 Q9R1S8
Rat Capn7 NM_001030037 Q499T5
Calpain 8 Human CAPN8 XM_001128157 A6NHC0
Rat Capn8 NM_133309 Q78EJ9
Calpain 9 Human CAPN9 NM_006615 O14815
Rat Capn9 XM_341719 O35920
Calpain 10 Human CAPN10 NM_023083 Q9HC92
Mouse Capn10 NM_011796 Q9ESK3
Rat Capn10 NM_031673 Q767K2
Calpain 11 Human CAPN11 NM_007058 Q9UMQ6
Mouse Capn11 NM_001013767 Q6J756
Rat Capn11 NM_001002806 Q4V8Q1
Calpain 12 Human CAPN12 NM_144691 Q6ZSI9
Mouse Capn12 NM_001110807 Q9ER56
Rat Capn12 NM_001110808 XP_218460
Calpain 13 Human CAPN13 NM_144575 Q6MZZ7
Mouse Capn13 NM_001033444 Q3UW68
Rat Capn13 NM_001025133 Q5BK10
Calpain 14 Human CAPN14 XR_017761 A8MX76
Cathepsins
Cathepsin A Human CTSA NM_000308 P10619
Mouse Ctsa NM_008906 P16675
Cathepsin B Human CTSB NM_147780 P07858
Mouse Ctsb NM_007798 P10605
Rat Ctsb NM_012838 P01041
Cathepsin C Human CTSC NM_001814 Q8WYA8
Mouse Ctsc NM_009982 P97821
Rat Ctsc NM_017097 P80067
Cathepsin D Human CTSD NM_001909 P07339
Mouse Ctsd NM_009983 P18242
Rat Ctsd NM_134334 Q6P6T6
Cathepsin E Human CTSE NM_001910 P14091
Mouse Ctse NM_007799 P70269
Rat Ctse NM_012938 P16228
Cathepsin F Human CTSF NM_003793 Q9UBX1
Mouse Ctsf NM_019861 Q9R013
Rat Ctsf NM_001034110 Q499S6
Cathepsin G Human CTSG NM_001911 P08311
Mouse Ctsg NM_007800 P28293
Rat Ctsg NM_001106041 P17977
Cathepsin H Human CTSH NM_004390 P09668
Mouse Ctsh NM_007801 P49935
Rat Ctsh NM_012939 P00786
Cathepsin K Human CTSK NM_000396 P43235
Mouse Ctsk NM_007802 P55097
Rat Ctsk NM_031560 O35186
Cathepsin L1 Human CTSL1 NM_001912 P07711
Mouse Ctsl NM_009984 P06797
Rat Ctsl1 NM_013156 P07154
Cathepsin L2 Human CTSL2 NM_001333 O60911
Cathepsin L3 Human CTSL3 NM_001023564 Q5NE16
Cathepsin O Human CTSO NM_001334 P43234
Mouse Ctso NM_177662 Q8BM88
Cathepsin S Human CTSS NM_004079 P25774
Mouse Ctss NM_021281 O70370
Rat Ctss NM_017320 Q02765
Cathepsin W Human CTSW NM_001335 P56202
Mouse Ctsw NM_009985 P56203
Rat Ctsw NM_001024242 Q561Q9
Cathepsin Z Human CTSZ NM_001336 Q9UBR2
Mouse Ctsz NM_022325 Q9WUU7
Rat Ctsz NM_183330 Q9R1T3