CA 074

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Cat.No. 4863 - CA 074 | C18H29N3O6 | CAS No. 134448-10-5
Description: Selective cathepsin B inhibitor
Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

M. Wt 383.44
Formula C18H29N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 134448-10-5
PubChem ID 9821383
InChI Key ZEZGJKSEBRELAS-PEDHHIEDSA-N
Smiles O=[C@](NCCC)[C@H]1O[C@@H]1[C@@](N[C@@H]([C@@H](C)CC)[C@](N2[C@H](C(O)=O)CCC2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.67 20
ethanol 7.67 20

Preparing Stock Solutions

The following data is based on the product molecular weight 383.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680 PMID: 19176528

Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311 PMID: 2013329

Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199 PMID: 22266111


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Keywords: CA 074, supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Cathepsin, Calcium-Sensitive, Proteases, Cathepsin, Tocris Bioscience

Citations for CA 074

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