CA 074
Biological Activity
Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.
Technical Data
| M. Wt | 383.44 |
| Formula | C18H29N3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 134448-10-5 |
| PubChem ID | 9821383 |
| InChI Key | ZEZGJKSEBRELAS-PEDHHIEDSA-N |
| Smiles | O=[C@](NCCC)[C@H]1O[C@@H]1[C@@](N[C@@H]([C@@H](C)CC)[C@](N2[C@H](C(O)=O)CCC2)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.67 | 20 | |
| ethanol | 7.67 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 383.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.04 mL | 65.2 mL | 130.4 mL |
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 2 mM | 1.3 mL | 6.52 mL | 13.04 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.61 mL |
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References
References are publications that support the biological activity of the product.
Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680 PMID: 19176528
Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311 PMID: 2013329
Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199 PMID: 22266111
If you know of a relevant reference for CA 074, please let us know.
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Keywords: CA 074, CA 074 supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Cathepsin, Calcium-Sensitive, Proteases, 4863, Tocris Bioscience
Citations for CA 074
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