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Biological Activity for Balicatib
Balicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.
Compound Libraries for Balicatib
Technical Data for Balicatib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Balicatib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Balicatib
The following data is based on the product molecular weight 411.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.15 mL||24.3 mL|
|5 mM||0.49 mL||2.43 mL||4.86 mL|
|10 mM||0.24 mL||1.21 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References for Balicatib
References are publications that support the biological activity of the product.
Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194
If you know of a relevant reference for Balicatib, please let us know.
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Keywords: Balicatib, Balicatib supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, 5585, Tocris Bioscience
Citations for Balicatib
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