Potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||4.12||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 411.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.15 mL||24.3 mL|
|5 mM||0.49 mL||2.43 mL||4.86 mL|
|10 mM||0.24 mL||1.21 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the products' biological activity.
Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194
If you know of a relevant reference for Balicatib, please let us know.
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Keywords: Balicatib, supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, Cathepsin, Tocris Bioscience
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