Balicatib

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Cat.No. 5585 - Balicatib | C23H33N5O2 | CAS No. 354813-19-7
Description: Potent and selective cathepsin K inhibitor
Chemical Name: N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

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Technical Data

M. Wt 411.54
Formula C23H33N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 354813-19-7
PubChem ID 10201696
InChI Key LLCRBOWRJOUJAE-UHFFFAOYSA-N
Smiles O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.15 100
ethanol 4.12 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 411.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194


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Keywords: Balicatib, supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, Cathepsin, Tocris Bioscience

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