Casein Kinase 2

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3058 Ellagic acid
Selective inhibitor of CK2. Also inhibits glutathione S-transferase
2275 TBB
Selective cell-permeable CK2 inhibitor
2825 TBCA
Selective CK2 inhibitor
3675 TMCB
Dual-kinase inhibitor; inhibits CK2 and ERK8
4432 TTP 22
High affinity, selective CK2 inhibitor

Related Targets

    Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory β-subunits and two catalytic units (α and α′) in a homomeric or heteromeric conformation.

    Whilst the α- and α′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the α- and not the α′-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (Myc, Jun, NF-κB). CK2 is also thought to influence Wnt signaling via β-catenin phosphorylation, and the PI 3-K signaling pathway via the phosphorylation of Akt.

    Literature for Casein Kinase 2

    Cancer

    Cancer Research Product Guide

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    • Receptor Signaling
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    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Neurodegeneration

    Neurodegeneration Product Guide

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    • Alzheimer's disease
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    Casein Kinase 2 (CK2) Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    CK2α Human CSNK2A1 NM_001895 P68400
    Mouse Csnk2a1 NM_007788 Q60737
    Rat Csnk2a1 NM_053824 P19139
    CK2α Human CSNK2A2 NM_001896 P19784
    Mouse Csnk2a2 NM_009974 O54833
    CK2β Human CSNK2B NM_001320 P67870
    Mouse Csnk2b NM_009975 P67871
    Rat Csnk2b NM_001035238 P67874