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Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.
|Cat. No.||Product Name / Activity|
|7450||SGC CK2-1 New|
|Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2|
|Selective cell-permeable CK2 inhibitor|
|Selective CK2 inhibitor|
|Dual-kinase inhibitor; inhibits CK2 and ERK8|
|High affinity, selective CK2 inhibitor|
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory β-subunits and two catalytic units (α and α′) in a homomeric or heteromeric conformation.
Whilst the α- and α′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the α- and not the α′-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (Myc, Jun, NF-κB). CK2 is also thought to influence Wnt signaling via β-catenin phosphorylation, and the PI 3-K signaling pathway via the phosphorylation of Akt.
Tocris offers the following scientific literature for Casein Kinase 2 to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|