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Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.
Casein Kinase 1 Inhibitors
|Cat. No.||Product Name / Activity|
|5329||CKI 7 dihydrochloride|
|CK1 inhibitor; also potently inhibits cdk1 and cdk2|
|Selective CK1 inhibitor. Also inhibits TGF-βRI|
|Potent CK1 inhibitor; also inhibits cyclin-dependent kinases|
|CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal|
|CK1 inhibitor; displays selectivity for CK1δ and CK1ε|
|Selective casein kinase 1δ inhibitor|
|4281||PF 4800567 hydrochloride|
|Selective casein kinase 1ε inhibitor|
|Potent CK1δ/ε inhibitor|
|Potent and selective CK1ε and CK1δ inhibitor|
|Potent and selective CK1δ and CK1ε inhibitor|
|Inhibitor of Wnt/β-catenin signaling; cross-reacts with CK1δ/ε|
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport.
CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1α is thought to phosphorylate β-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1ε phosphorylates the intracellular signaling protein, Dishevelled and CK1γ directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1α plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1α phosphorylates the 7-TM co-receptor, Smoothened.
Tocris offers the following scientific literature for Casein Kinase 1 to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|