Casein Kinase 1

Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5329 CKI 7 dihydrochloride
CK1 inhibitor
3605 (R)-CR8
Dual cdk/CK1 inhibitor
2902 D 4476
Selective CK1 inhibitor. Also inhibits TGF-βRI
3610 (R)-DRF053 dihydrochloride
Dual CK1/cdk inhibitor
4896 LH 846
Selective casein kinase 1δ inhibitor
4281 PF 4800567 hydrochloride
Selective casein kinase 1ε inhibitor
3316 PF 670462
Potent and selective CK1ε and CK1δ inhibitor
5383 TA 01
CK1ε and CK1δ inhibitor; also inhibits p38α
5384 TA 02
CK1ε and CK1δ inhibitor; also inhibits p38α
4254 TAK 715
Inhibitor of Wnt/β-catenin signaling; cross-reacts with CK1δ/ε

Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport.

CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1α is thought to phosphorylate β-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1ε phosphorylates the intracellular signaling protein, Dishevelled and CK1γ directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1α plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1α phosphorylates the 7-TM co-receptor, Smoothened.

Literature for Casein Kinase 1

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Casein Kinase 1 (CK1) Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CK1α Human CSNK1A1 NM_001892 P48729
Mouse Csnk1a1 NM_146087 Q8BK63
Rat Csnk1a1 NM_053615 P97633
CK1δ Human CSNK1D NM_139062 P48730
Mouse Csnk1d NM_027874 Q9DC28
Rat Csnk1d NM_139060 Q06486
CK1ε Human CSNK1E NM_001894 P49674
Mouse Csnk1e NM_013767 Q9JMK2
Rat Csnk1e U02889 Q62602
CK1γ1 Human CSNK1G1 NM_022048 Q9HCP0
Mouse Csnk1g1 NM_173185 Q8BTH8
Rat Csnk1g1 NM_022288 Q62761
CK1γ2 Human CSNK1G2 NM_001319 P78368
Mouse Csnk1g2 NM_134002 Q8BVP5
Rat Csnk1g2 NM_022288 Q62761
CK1γ3 Human CSNK1G3 NM_004384 Q9Y6M4
Mouse Csnk1g3 NM_152809 Q8C4X2
Rat Csnk1g3 NM_022855 Q62763