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Biological Activity for SGC CK2-1
SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC50 values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC50 = 440 nM).
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.
External Portal Information for SGC CK2-1
Compound Libraries for SGC CK2-1
Technical Data for SGC CK2-1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SGC CK2-1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SGC CK2-1
The following data is based on the product molecular weight 375.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.66 mL||13.32 mL||26.64 mL|
|5 mM||0.53 mL||2.66 mL||5.33 mL|
|10 mM||0.27 mL||1.33 mL||2.66 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References for SGC CK2-1
References are publications that support the biological activity of the product.
Wells et al (2021) Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem.Biol. 28 546 PMID: 33484635
If you know of a relevant reference for SGC CK2-1, please let us know.
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Keywords: SGC CK2-1, SGC CK2-1 supplier, SGCCK2-1, SGCCK21, casein, kinases, inhibitors, CK2, CK2A2, CK2A1, DYRK2, potent, SGC, Casein, Kinase, 2, DYRK, 7450, Tocris Bioscience
1 Citation for SGC CK2-1
Citations are publications that use Tocris products. Selected citations for SGC CK2-1 include:
Carmine et al (2022) Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Sci Adv 8 eabo1215 PMID: 36044577
Do you know of a great paper that uses SGC CK2-1 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cell Cycle and DNA Damage Research Product Guide
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