TTP 22

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Cat.No. 4432 - TTP 22 | C16H14N2O2S2 | CAS No. 329907-28-0
Description: High affinity, selective CK2 inhibitor
Chemical Name: 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

Compound Libraries

TTP 22 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 330.42
Formula C16H14N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 329907-28-0
PubChem ID 1536915
InChI Key RAOULLCLLOGTDA-UHFFFAOYSA-N
Smiles CC(C=C3)=CC=C3C1=CSC2=C1C(SCCC(O)=O)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.04 100
ethanol 6.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Golub et al (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 46 870 PMID: 21276643


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Keywords: casein kinase 2 CK2 inhibits inhibitors selective high affinity ATP competitive TTP22 Casein Kinase 2

Citations for TTP 22

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Literature in this Area

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Neurodegeneration

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Pathways for TTP 22

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