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Biological Activity for TTP 22
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).
Compound Libraries for TTP 22
Technical Data for TTP 22
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TTP 22
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TTP 22
The following data is based on the product molecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.03 mL||15.13 mL||30.26 mL|
|5 mM||0.61 mL||3.03 mL||6.05 mL|
|10 mM||0.3 mL||1.51 mL||3.03 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References for TTP 22
References are publications that support the biological activity of the product.
Golub et al (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 46 870 PMID: 21276643
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Keywords: TTP 22, TTP 22 supplier, casein, kinase, 2, CK2, inhibits, inhibitors, selective, high, affinity, ATP, competitive, TTP22, Casein, Kinase, 4432, Tocris Bioscience
Citations for TTP 22
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Literature in this Area
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