Ca2+-ATPase

Ca2+-ATPases function to maintain a low cytoplasmic concentration of Ca2+ ions. They are high affinity, low capacitance transporters and complement the actions of the low affinity, high capacitance Na+/Ca2+ exchanger. Ca2+-ATPases are P-type ATPases.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
2668 Artemisinin
Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
1236 BHQ
Inhibitor of SERCA ATPase
1235 Cyclopiazonic acid
Inhibitor of SERCA ATPase
1138 Thapsigargin
Potent inhibitor of SERCA ATPase

Activators

Cat No Product Name / Activity
5869 CDN 1163
SERCA2 allosteric activator
3807 Disulfiram
Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities
1291 Ochratoxin A
Stimulates SERCA-ATP-dependent Ca2+ pump activity

Blockers

Cat No Product Name / Activity
2006 Paxilline
SERCA ATPase blocker. Also potent BKCa channel blocker

Ca2+-ATPases function to maintain a low cytoplasmic concentration of Ca2+ ions. They are high affinity, low capacitance transporters and complement the actions of the low affinity, high capacitance Na+/Ca2+ exchanger. Ca2+-ATPases are P-type ATPases and there are two variants: a plasma membrane-bound Ca2+-ATPase (PMCA) and a sacroplasmic reticulum Ca2+-ATPase (SERCA).

PMCA exists as a dimer within the plasma membrane of a wide variety of cell types and, using the energy released from ATP hydrolysis, transports Ca2+ ions out of the cell against the concentration gradient. SERCA is located in the sarcoplasmic reticulum (SR) of muscle cells and transports Ca2+ ions from the cytoplasm into the SR lumen during muscle relaxation. PMCA transports one Ca2+ ion per ATP molecule hydrolyzed, whilst SERCA can transport two. PMCAs are regulated by calmodulin and the phospholipid composition of the surrounding plasma membrane. Furthermore, PMCA can be phosphorylated by PKA, PKC, Src and FAK at specific residues to influence activity.

So far, only one human pathology has been linked to PMCA defects - deafness. However, SERCA defects have been implicated in a wide array of pathologies including heart failure, sperm motility defects, cataract formation, carcinogenesis, diabetes, and cardiac hypertension and hypertrophy.

Ca2+-ATPase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
SERCA1 Human ATP2A1 NM_004320 O14983
Mouse Atp2a1 NM_007504 Q8R429
Rat Atp2a1 NM_058213 Q64578
SERCA2 Human ATP2A2 NM_001681 P16615
Mouse Atp2a2 NM_001110140 O55143
Rat Atp2a2 NM_017290 P11507
SERCA3 Human ATP2A3 NM_174953 Q93084
Mouse Atp2a3 NM_016745 Q64518
Rat Atp2a3 NM_012914 P18596
PMCA1 Human ATP2B1 NM_001001323 P20020
Mouse Atp2b1 NM_026482 NP_080758
Rat Atp2b1 NM_053311 P11505
PMCA2 Human ATP2B2 NM_001683 Q01814
Mouse Atp2b2 NM_009723 Q9R0K7
Rat Atp2b2 NM_012508 P11506
PMCA3 Human ATP2B3 NM_001001344 Q16720
Mouse Atp2b3 NM_177236 NP_796210
Rat Atp2b3 NM_133288 Q5EB74
PMCA4 Human ATP2B4 NM_001001396 P23634
Mouse Atp2b4 NM_213616 NP_998781
Rat Atp2b4 NM_001005871 Q64542