Protein Kinase A

Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
1337 cAMPS-Rp, triethylammonium salt
cAMP antagonist; inhibits PKA activation
0541 Fasudil hydrochloride
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
1883 cGMP Dependent Kinase Inhibitor Peptide
Inhibitor of protein kinases G and A
2910 H 89 dihydrochloride
Protein kinase A inhibitor
1288 KT 5720
Selective protein kinase A inhibitor
1904 PKA inhibitor fragment (6-22) amide
Potent protein kinase A inhibitor
6221 PKI (5-24)
High affinity PKA inhibitor
2546 PKI 14-22 amide, myristoylated
Cell-permeable protein kinase A inhibitor

Activators

Cat No Product Name / Activity
1333 cAMPS-Sp, triethylammonium salt
Cell-permeable cAMP analog; activates PKA
1140 8-Bromo-cAMP, sodium salt
Membrane permeable cAMP analog; activates PKA
5495 CW 008
PKA signaling activator; promotes osteogenesis from hMSCs

Ligand-sets

Cat No Product Name / Activity
1882 PKA Tocriset™
Selection of 5 PKA modulators (Cat. Nos. 1337, 1140, 1099, 1288 and 1603)

Other

Cat No Product Name / Activity
6286 st-Ht31
Inhibits PKA/AKAP interactions; cell permeable
6287 st-Ht31 P
Negative control for st-Ht31 (Cat. No. 6286)

Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIα- and RIβ-, RIIα- and RIIβ-).

Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

External sources of pharmacological information for Protein Kinase A :

    Protein Kinase A Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Catalytic Cα Human PRKACA NM_002730 P17612
    Mouse Prkaca NM_008854 P05132
    Rat Prkaca NM_001100922 P27791
    Catalytic Cβ Human PRKACB NM_182948 P22694
    Mouse Prkacb NM_011100 P68181
    Rat Prkacb NM_001077645 P68182
    Catalytic Cγ Human PRKACG NM_002732 P22612
    Regulatory RIα Human PRKAR1A NM_212472 P10644
    Mouse Prkar1a NM_021880 Q9DBC7
    Rat Prkar1a NM_013181 P09456
    Regulatory RIIα Human PRKAR2A NM_004157 P13861
    Mouse Prkar2a NM_008924 P12367
    Rat Prkar2a NM_019264 P12368
    Regulatory RIβ Human PRKAR1B NM_002735 P31321
    Mouse Prkar1b NM_008923 P12849
    Rat Prkar1b NM_001033679 P81377
    Regulatory RIIβ Human PRKAR2B NM_002736 P31323
    Mouse Prkar2b NM_011158 P31324
    Rat Prkar2b NM_001030020 P12369