Protein Kinase A

Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Products
Background
Literature (3)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
1337 cAMPS-Rp, triethylammonium salt
cAMP antagonist; inhibits PKA activation
7001 AT 7867
Potent pan-Akt and PKA inhibitor
0541 Fasudil hydrochloride
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
1883 cGMP Dependent Kinase Inhibitor Peptide
Inhibitor of protein kinases G and A
2910 H 89 dihydrochloride
Protein kinase A inhibitor
1288 KT 5720
Selective protein kinase A inhibitor
1904 PKA inhibitor fragment (6-22) amide
Potent protein kinase A inhibitor
6221 PKI (5-24)
High affinity PKA inhibitor
2546 PKI 14-22 amide, myristoylated
Cell-permeable protein kinase A inhibitor

Activators

Cat. No. Product Name / Activity
1333 cAMPS-Sp, triethylammonium salt
Cell-permeable cAMP analog; activates PKA
1140 8-Bromo-cAMP, sodium salt
Membrane permeable cAMP analog; activates PKA
5495 CW 008
PKA signaling activator; promotes osteogenesis from hMSCs

Ligand Sets

Cat. No. Product Name / Activity
1882 PKA Tocriset™
Selection of 5 PKA modulators (Cat. Nos. 1337, 1140, 1099, 1288 and 1603)

Other

Cat. No. Product Name / Activity
6286 st-Ht31
Inhibits PKA/AKAP interactions; cell permeable
6287 st-Ht31 P
Negative control for st-Ht31 (Cat. No. 6286)

Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIα- and RIβ-, RIIα- and RIIβ-).

Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

External sources of pharmacological information for Protein Kinase A :

Literature for Protein Kinase A

Tocris offers the following scientific literature for Protein Kinase A to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Protein Kinase A Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Catalytic Cα Human PRKACA NM_002730 P17612
Mouse Prkaca NM_008854 P05132
Rat Prkaca NM_001100922 P27791
Catalytic Cβ Human PRKACB NM_182948 P22694
Mouse Prkacb NM_011100 P68181
Rat Prkacb NM_001077645 P68182
Catalytic Cγ Human PRKACG NM_002732 P22612
Regulatory RIα Human PRKAR1A NM_212472 P10644
Mouse Prkar1a NM_021880 Q9DBC7
Rat Prkar1a NM_013181 P09456
Regulatory RIIα Human PRKAR2A NM_004157 P13861
Mouse Prkar2a NM_008924 P12367
Rat Prkar2a NM_019264 P12368
Regulatory RIβ Human PRKAR1B NM_002735 P31321
Mouse Prkar1b NM_008923 P12849
Rat Prkar1b NM_001033679 P81377
Regulatory RIIβ Human PRKAR2B NM_002736 P31323
Mouse Prkar2b NM_011158 P31324
Rat Prkar2b NM_001030020 P12369