Calcium Channels

Calcium is a vital signaling molecule that mediates muscle contraction, neurotransmission, gene expression and more. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels, such as IP3 receptors, store operated calcium channels and ryanodine receptors, which are activated by ligand binding.

Targets
Literature
Ion Channel Data

Multiple diseases are caused by disruption of normal calcium channel function. Inherited calcium channelopathies include nervous system disorders, such as X-linked night blindness and hemiplegic migraine, muscloskeletal disorders, such as hypokalemic periodic paralysis and malignant hyperthermia, and cardiovascular disorders, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia.

Literature for Calcium Channels

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
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Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Properties of Voltage-gated Calcium Channels

Channel Type L T N P Q R
Conductance (pS) 25 5-9 ~ 20 9-19 16 -
Activation Threshold High Low High High High High
Deactivation Rate Fast Slow Fast Fast Fast Fast
Inactivation Rate Slow Fast Moderate Very Slow Moderate Fast
Permeability Ba2+ > Ca2+ Ba2+ = Ca2+ Ba2+ > Ca2+ Ba2+ > Ca2+ Ba2+ > Ca2+ Ba2+ > Ca2+

References

Perez-Reyes and Schneider (1994) Calcium channels: structure, function, and classification. Drug Dev.Res. 33 295. Catterall (1995) Structure and function of voltage-gated ion channels. Ann.Rev.Biochem. 64 493.