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Calcium is a vital signaling molecule that mediates muscle contraction, neurotransmission, gene expression and more. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential and ligand-gated calcium channels, such as IP3 receptors, store operated calcium channels and ryanodine receptors, which are activated by ligand binding.
Multiple diseases are caused by disruption of normal calcium channel function. Inherited calcium channelopathies include nervous system disorders, such as X-linked night blindness and hemiplegic migraine, muscloskeletal disorders, such as hypokalemic periodic paralysis and malignant hyperthermia, and cardiovascular disorders, including ventricular cardiomyopathy and familial polymorphic ventricular tachycardia.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
|Conductance (pS)||25||5-9||~ 20||9-19||16||-|
|Inactivation Rate||Slow||Fast||Moderate||Very Slow||Moderate||Fast|
|Permeability||Ba2+ > Ca2+||Ba2+ = Ca2+||Ba2+ > Ca2+||Ba2+ > Ca2+||Ba2+ > Ca2+||Ba2+ > Ca2+|
Perez-Reyes and Schneider (1994) Calcium channels: structure, function, and classification. Drug Dev.Res. 33 295. Catterall (1995) Structure and function of voltage-gated ion channels. Ann.Rev.Biochem. 64 493.