CDN 1163

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Cat.No. 5869 - CDN 1163 | C20H20N2O2 | CAS No. 892711-75-0
Description: SERCA2 allosteric activator
Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity

SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective and improves memory and cognition in a mouse Alzheimer's disease model. Orally bioavailable.

Technical Data

M. Wt 320.38
Formula C20H20N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 892711-75-0
PubChem ID 16016585
InChI Key GVGVYDCVFBGALZ-UHFFFAOYSA-N
Smiles CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 32.04 100
DMSO 32.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185 PMID: 26702054

Krajnak and Dahl et al (2018) A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg.Med.Chem.Lett. 28 1591 PMID: 29602679


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Keywords: CDN 1163, CDN 1163 supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Other, stress/UPR, 5869, Tocris Bioscience

1 Citation for CDN 1163

Citations are publications that use Tocris products. Selected citations for CDN 1163 include:

Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652


Do you know of a great paper that uses CDN 1163 from Tocris? Please let us know.

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