CDN 1163

Pricing Availability Delivery Time Qty
Cat.No. 5869 - CDN 1163 | C20H20N2O2 | CAS No. 892711-75-0
Description: SERCA2 allosteric activator
Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice.

Technical Data

M. Wt 320.38
Formula C20H20N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 892711-75-0
PubChem ID 16016585
InChI Key GVGVYDCVFBGALZ-UHFFFAOYSA-N
Smiles CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.04 100
ethanol 32.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185 PMID: 26702054


If you know of a relevant reference for CDN 1163, please let us know.

View Related Products by Product Action

View all Ca2+-ATPase Activators

Keywords: CDN1163 allosteric activators sarco/endoplasmic reticulum Ca2+-ATPase activates ER stress SERCA2b type II diabetes T2D Ca2+-ATPase

1 Citation for CDN 1163

Citations are publications that use Tocris products. Selected citations for CDN 1163 include:

Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652


Do you know of a great paper that uses CDN 1163 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for CDN 1163

Protocols

TODO: Add Protocols