SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.12 mL||15.61 mL||31.21 mL|
|5 mM||0.62 mL||3.12 mL||6.24 mL|
|10 mM||0.31 mL||1.56 mL||3.12 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185 PMID: 26702054
If you know of a relevant reference for CDN 1163, please let us know.
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Keywords: CDN1163 allosteric activators sarco/endoplasmic reticulum Ca2+-ATPase activates ER stress SERCA2b type II diabetes T2D Ca2+-ATPase
1 Citation for CDN 1163
Citations are publications that use Tocris products. Selected citations for CDN 1163 include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
Do you know of a great paper that uses CDN 1163 from Tocris? If so please let us know.