p53

More Information »p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs.

p53 Products

Inhibitors
Cat.No.
Product Name / Activity
1267 Pifithrin-α hydrobromide
p53 inhibitor. Also aryl hydrocarbon receptor agonist
3843 Cyclic Pifithrin-α hydrobromide
p53 inhibitor
2653 Pifithrin-μ
Inhibitor of p53-mitochondrial binding
Activators
Cat.No.
Product Name / Activity
3503 HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
2185 NSC 146109 hydrochloride
Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
5065 NSC 319726
Reactivator of mutant p53
2936 NSC 66811
MDM2 inhibitor. Disrupts MDM2-p53 interaction
3984 Nutlin-3
MDM2 antagonist; inhibits MDM2-p53 interaction
2443 RITA
p53-MDM2 interaction inhibitor; antitumor
3929 SJ 172550
MDMX inhibitor. Disrupts MDMX-p53 interaction
5332 SP 141
High affinity MDM2 inhibitor
3365 Tenovin-1
Activates p53 transcriptional activity
3356 WR 1065
p53 activator. Also ROS scavenger
Other
Cat.No.
Product Name / Activity
5417 BMH 21
p53 pathway activator; also RNA polymerase 1 inhibitor
3023 CP 31398 dihydrochloride
p53-stabilizing agent
3362 MIRA-1
Restores mutant p53 activity; proapoptotic
4326 PhiKan 083
p53 stabilizing agent
4396 Piperlongumine
Induces apoptosis; increases p53 and ROS levels in cancer cells
4761 Plumbagin
Induces p53 Ser10 phosphorylation; anticancer
1862 PRIMA-1
Restores mutant p53 activity; induces apoptosis
3710 PRIMA-1MET
Restores mutant p53 activity
3214 RETRA hydrochloride
Antitumor agent; suppresses mutant p53-bearing cancer cells
4240 SCH 529074
Restores mutant p53 activity
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