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PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
PRIMA-1MET is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 199.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.02 mL||25.09 mL||50.19 mL|
|5 mM||1 mL||5.02 mL||10.04 mL|
|10 mM||0.5 mL||2.51 mL||5.02 mL|
|50 mM||0.1 mL||0.5 mL||1 mL|
References are publications that support the biological activity of the product.
Bykov et al (2005) PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis. Oncogene 24 3484 PMID: 15735745
Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571 PMID: 18663359
Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23 PMID: 19323829
If you know of a relevant reference for PRIMA-1MET, please let us know.
Keywords: PRIMA-1MET, PRIMA-1MET supplier, Restores, mutant, p53, activity, transcription, factors, APR-246, 3710, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for PRIMA-1MET include:
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
Do you know of a great paper that uses PRIMA-1MET from Tocris? Please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.