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Description: Restores mutant p53 activity
Alternative Names: APR-246
Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Purity: ≥98% (HPLC)
Citations (3)
Literature (2)
Pathways (1)

Biological Activity for PRIMA-1MET

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Compound Libraries for PRIMA-1MET

PRIMA-1MET is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for PRIMA-1MET

M. Wt 199.25
Formula C10H17NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 5291-32-7
PubChem ID 52918385
Smiles OCC1(COC)C(C2CCN1CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PRIMA-1MET

Solvent Max Conc. mg/mL Max Conc. mM
water 19.93 100
DMSO 19.93 100

Preparing Stock Solutions for PRIMA-1MET

The following data is based on the product molecular weight 199.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.02 mL 25.09 mL 50.19 mL
5 mM 1 mL 5.02 mL 10.04 mL
10 mM 0.5 mL 2.51 mL 5.02 mL
50 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets for PRIMA-1MET

Certificate of Analysis / Product Datasheet
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References for PRIMA-1MET

References are publications that support the biological activity of the product.

Bykov et al (2005) PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis. Oncogene 24 3484 PMID: 15735745

Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571 PMID: 18663359

Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23 PMID: 19323829

If you know of a relevant reference for PRIMA-1MET, please let us know.

View Related Products by Target

Keywords: PRIMA-1MET, PRIMA-1MET supplier, Restores, mutant, p53, activity, transcription, factors, APR-246, 3710, Tocris Bioscience

3 Citations for PRIMA-1MET

Citations are publications that use Tocris products. Selected citations for PRIMA-1MET include:

Kunle O et al (2022) Estrogen Receptor-Beta2 (ERβ2)-Mutant p53-FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC). Cancers (Basel) 14 PMID: 35267428

Katja et al (2022) Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype. Mol Cancer Ther 21 1236-1245 PMID: 35364610

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703

Do you know of a great paper that uses PRIMA-1MET from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PRIMA-1MET

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.