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Biological Activity for PRIMA-1MET
PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
Compound Libraries for PRIMA-1MET
Technical Data for PRIMA-1MET
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PRIMA-1MET
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PRIMA-1MET
The following data is based on the product molecular weight 199.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.02 mL||25.09 mL||50.19 mL|
|5 mM||1 mL||5.02 mL||10.04 mL|
|10 mM||0.5 mL||2.51 mL||5.02 mL|
|50 mM||0.1 mL||0.5 mL||1 mL|
References for PRIMA-1MET
References are publications that support the biological activity of the product.
Bykov et al (2005) PRIMA-1MET synergizes with cisp. to induce tumor cell apoptosis. Oncogene 24 3484 PMID: 15735745
Shen et al (2008) PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571 PMID: 18663359
Stuber et al (2009) PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23 PMID: 19323829
If you know of a relevant reference for PRIMA-1MET, please let us know.
Keywords: PRIMA-1MET, PRIMA-1MET supplier, Restores, mutant, p53, activity, transcription, factors, APR-246, 3710, Tocris Bioscience
1 Citation for PRIMA-1MET
Citations are publications that use Tocris products. Selected citations for PRIMA-1MET include:
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.