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Biological Activity for MIRA-1
MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
Technical Data for MIRA-1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MIRA-1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MIRA-1
The following data is based on the product molecular weight 183.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.46 mL||27.3 mL||54.6 mL|
|5 mM||1.09 mL||5.46 mL||10.92 mL|
|10 mM||0.55 mL||2.73 mL||5.46 mL|
|50 mM||0.11 mL||0.55 mL||1.09 mL|
References for MIRA-1
References are publications that support the biological activity of the product.
Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384 PMID: 15998635
Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921 PMID: 16557267
Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168 PMID: 17485365
If you know of a relevant reference for MIRA-1, please let us know.
Keywords: MIRA-1, MIRA-1 supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors, 3362, Tocris Bioscience
1 Citation for MIRA-1
Citations are publications that use Tocris products. Selected citations for MIRA-1 include:
Saha et al (2014) Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br J Cancer 110 2224 PMID: 24691427
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.