Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 183.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.46 mL||27.3 mL||54.6 mL|
|5 mM||1.09 mL||5.46 mL||10.92 mL|
|10 mM||0.55 mL||2.73 mL||5.46 mL|
|50 mM||0.11 mL||0.55 mL||1.09 mL|
References are publications that support the biological activity of the product.
Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384 PMID: 15998635
Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921 PMID: 16557267
Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168 PMID: 17485365
If you know of a relevant reference for MIRA-1, please let us know.
Keywords: MIRA-1, MIRA-1 supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors, 3362, Tocris Bioscience
1 Citation for MIRA-1
Citations are publications that use Tocris products. Selected citations for MIRA-1 include:
Saha et al (2014) Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br J Cancer 110 2224 PMID: 24691427
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.