Bcl-2 Family

Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
4676 ARRY 520 trifluoroacetate
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160 Bax channel blocker
Inhibits Bax-mediated mitochondrial cytochrome c release
1785 Bax inhibitor peptide V5
Inhibitor of Bax-mediated apoptosis
1787 Bax inhibitor peptide, negative control
Negative control peptide for Bax inhibitor peptide V5 (Cat. No. 1785)
3590 Gambogic acid
Apoptosis inducer. Inhibits Bcl-2 family proteins
1541 HA14-1
Bcl-2 inhibitor. Induces apoptosis
3794 iMAC2
Inhibitor of Bid-induced Bax cytochrome c release
5368 Maritoclax
Mcl-1 inhibitor; proapoptotic
4819 Methylprednisolone
Anti-apoptotic; upregulates expression of Bcl-xL after injury
4762 MIM1
Mcl-1 inhibitor; proapoptotic
4038 TW 37
Bcl-2 inhibitor; induces apoptosis

Activators

Cat No Product Name / Activity
4810 BAM 7
Selective Bax activator; induces Bax-mediated apoptosis
5314 SMBA 1
High affinity and selective activator of Bax

Other

Cat No Product Name / Activity
3367 AT 101
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
3526 BIM, Biotinylated
Bim peptide fragment
2137 2,3-DCPE hydrochloride
Downregulates Bcl-XL protein expression
1964 Gossypol
Proapoptotic; downregulates Bcl-2 and Bcl-XL
3816 Muristerone A
Stimulates Bcl-XL mRNA transcription; antiapoptotic
2907 SU 9516
Transcriptionally downregulates Mcl-1; proapoptotic

Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. They comprise a large protein family and all members contain at least one of four BH (Bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-XL and Mcl-1 are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

The proapoptotic group of Bcl-2 proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (including Bid, NOXA, PUMA and Bad) and the multidomain proteins that share BH1 to 3 (including Bax and Bak). Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes.

The Bcl-2 gene has been linked to the development and therapeutic resistance of numerous different cancers.

Literature for Bcl-2 Family

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bcl-2 Family

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Bcl-2 Family Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Bcl-2 Human BCL2 NM_000633 P10415
Mouse Bcl2 NM_009741 P10417
Rat Bcl2 NM_016993 P49950
Bcl-xL, Bcl-xS Human BCL2L1 NM_138578 Q07817
Mouse Bcl2l1 NM_009743 Q64373
Rat Bcl2l1 NM_001033672 P53563
Bax Human BAX NM_138763 Q07812
Mouse Bax NM_007527 Q07813
Rat Bax NM_017059 Q63690
Bak Human BAK1 NM_001188 Q16611
Mouse Bak1 NM_007523 O08734
Rat Bak1 NM_053812 Q9JK59
Mcl-1 Human MCL1 NM_021960 Q07820
Mouse Mcl1 NM_008562 P97287
Rat Mcl1 NM_021846 Q9Z1P3
Bfl-1/A1 Human BCL2A1 NM_004049 Q16548
Mouse Bcl2a1 NM_009742 Q07440
Rat Bcl2a1 NM_133416 Q925A9
Bcl-w Human BCL2L2 NM_004050 Q92843
Mouse Bcl2l2 NM_007537 P70345
Rat Bcl2l2 NM_021850 O88996
Mtd Human BOK NM_032515 Q9UMX3
Mouse Bok NM_016778 O35425
Rat Bok NM_017312 Q792S6
Diva Human BCL2L10 NM_020396 Q9HD36
Mouse Bcl2l10 NM_013479 Q9Z0F3
Rat Bcl2l10 NM_053733 Q99M66
Bcl-G Human BCL2L14 NM_030766 Q9BZR8
Mouse Bcl2l14 NM_025778 Q9CPT0
Bpr Human BCL2L12 NM_052842 Q9HB09
Mouse Bcl2l12 NM_029410 NP_083686
Rat Bcl2l12 NM_001108480 NP_001101950
Hrk Human HRK NM_003806 O00198
Mouse Hrk NM_007545 P62816
Rat Hrk NM_057130 P62817
Bik, Nbk, Blk Human BIK NM_001197 Q13323
Mouse Bik NM_007546 NP_031572
Rat Bik NM_053704 Q925D2
Bid Human BID NM_001196 P55957
Mouse Bid NM_007544 P70444
Rat Bid NM_022684 Q9JLT6
Bad Human BAD NM_032989 Q92934
Mouse Bad NM_007522 Q61337
Rat Bad NM_022698 O35147
Bim Human BCL2L11 NM_006538 O43521
Mouse Bcl2l11 NM_207680 O54918
Rat Bcl2l11 NM_171988 O88498
Puma Human BBC3 NM_014417 Q9BXH1
Mouse Bbc3 NM_133234 Q99ML1
Rat Bbc3 NM_173837 Q80ZG6
Noxa, Apr Human PMAIP1 NM_021127 Q13794
Mouse Pmaip1 NM_021451 NP_067426
Rat Pmaip1 NM_001008385 Q5U777