AMPK Signaling Pathway

Pathway Key Download PDF

Leptin
Receptor Insulin
Receptor PI3K mTOR p70
S6K p53 eNOS Rheb PKA HMG-CoA
Reductase Fatty acid
Synthase Glycogen
Synthase AMPK Akt Protein Synthesis α-adrenergic
receptor cAMP PLCβ SREBP1 GLUT4

The AMP-activated protein kinase (AMPK) has an important role in the regulation of cellular energy homeostasis. The enzyme is activated under conditions of low ATP, often caused by a variety of stresses and regulates signaling pathways that increase the supplies of ATP available.

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Signaling Pathway Key

Stimulates

Inhibits

Multistep Activation

Translocates

Kinase

Transcription Factor

Enzyme-linked Receptor

Other Enzyme

Other Protein

7-TM Receptor