Leptin Receptors

Leptin was initially thought to have a role in energy homeostasis and obesity. It acts via leptin receptors (Ob-Rs), which are transmembrane catalytic receptors found on NPY/AgRP and α-MSH/CART neurons in hypothalamic nuclei. There are six isoforms of Ob-R.

Products
Background
Literature
Gene Data
Cat No Product Name / Activity
2985 LEP (116-130) (mouse)
Synthetic leptin peptide fragment

Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on NPY/AgRP and α-MSH/CART neurons in hypothalamic nuclei.

Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra to Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression.

Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity.

Literature for Leptin Receptors

Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Leptin Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human LEPR NM_002303 P48357
Mouse Lepr NM_001122899 P48356
Rat Lepr NM_012596 Q9JHF4