Glucose Transporters

Glucose transporters enable the movement of glucose, a hydrophilic molecule, across the cell membrane. Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
6199 BAY 876
Potent and selective GLUT1 inhibitor
6100 Fasentin
GLUT1/GLUT4 inhibitor; also Fas-sensitizer
4484 STF 31
GLUT1 inhibitor; also NAMPT inhibitor
6143 WZB 117
GLUT inhibitor

Other

Cat No Product Name / Activity
5734 L-Dehydroascorbic acid
GLUT1 substrate; oxidized form of L-Ascorbic acid
5504 D-(+)-Glucose
Naturally occurring monosaccharide
3506 NVP DPP 728 dihydrochloride
DPP-IV inhibitor; augments GLUT2 levels

Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.

Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.

Literature for Glucose Transporters

Tocris offers the following scientific literature for Glucose Transporters to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Glucose Transporter Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Solute carrier family 2 (facilitated glucose transporter), member 1
(GLUT1)
Human SLC2A1 NM_006516 P11166
Mouse Slc2a1 NM_011400 P17809
Rat Slc2a1 NM_138827 P11167
Solute carrier family 2 (facilitated glucose transporter), member 2
(GLUT2)
Human SLC2A2 NM_000340 P11168
Mouse Slc2a2 NM_031197 P14246
Rat Slc2a2 NM_012879 P12336
Solute carrier family 2 (facilitated glucose transporter), member 3
(GLUT3)
Human SLC2A3 NM_006931 P11169
Mouse Slc2a3 NM_011401 P32037
Rat Slc2a3 NM_017102 Q6P506
Solute carrier family 2 (facilitated glucose transporter), member 4
(GLUT4)
Human SLC2A4 NM_001042 P14672
Mouse Slc2a4 NM_009204 P14142
Rat Slc2a4 NM_012751 P19357
Solute carrier family 2 (facilitated glucose transporter), member 5
(GLUT5)
Human SLC2A5 NM_003039 P22732
Mouse Slc2a5 NM_019741 Q9WV38
Rat Slc2a5 NM_031741 P43427
Solute carrier family 2 (facilitated glucose transporter), member 6
(GLUT6)
Human SCL2A6 NM_017585 Q9UGQ3
Mouse Slc2a6 NM_172659 Q3UDF0
Rat Slc2a6 NM_001106562 EDL93446
Solute carrier family 2 (facilitated glucose transporter), member 7
(GLUT7)
Human SCL2A7 NM_207420 Q6PXP3
Mouse Slc2a7 NM_001085529 B1ARZ3
Rat Slc2a7 NM_001101020 A4ZYQ5
Solute carrier family 2 (facilitated glucose transporter), member 8
(GLUT8)
Human SLC2A8 NM_014580 Q9NY64
Mouse Slc2a8 NM_019488 Q9IJF3
Rat Slc2a8 NM_053494 Q9JJZ1
Solute carrier family 2 (facilitated glucose transporter), member 9
(GLUT9)
Human SCL2A9 NM_001001290 Q9NRM0
Mouse Slc2a9 NM_001102414 Q3T9X0
Rat - - -
Solute carrier family 2 (facilitated glucose transporter), member 10
(GLUT10)
Human SLC2A10 NM_030777 O95528
Mouse Slc2a10 NM_130451 Q8VHD6
Rat Slc2a10 NM_001108963 EDL96452
Solute carrier family 2 (facilitated glucose transporter), member 11
(GLUT11)
Human SLC2A11 NM_030807 Q9BYW1
Mouse - - -
Rat - - -
Solute carrier family 2 (facilitated glucose transporter), member 12
(GLUT12)
Human SLC2A12 NM_145176 Q8TD20
Mouse Slc2a12 NM_178934 Q8BFW9
Rat Slc2a12 NM_001107451 EDL87731
Solute carrier family 2 (facilitated glucose transporter), member 13
(HMIT)
Human SLC2A13 NM_052885 Q96QE2
Mouse Slc2a13 NM_001033633 Q3UHK1
Rat Slc2a13 NM_133611 Q921A2