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Glucose Transporters

Glucose transporters enable the movement of glucose, a hydrophilic molecule, across the cell membrane. Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis.

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Products
Background
Literature (2)
Gene Data

Glucose Transporter Inhibitors
Cat. No. Product Name / Activity
6199 BAY 876
Potent and selective GLUT1 inhibitor
6100 Fasentin
GLUT1/GLUT4 inhibitor; also Fas-sensitizer
4484 STF 31
GLUT1 inhibitor; also NAMPT inhibitor
6143 WZB 117
GLUT inhibitor

Other
Cat. No. Product Name / Activity
6065 2-NBDG
Fluorescent glucose uptake indicator
7447 SCOTfluor glucose probe 510
Fluorescent glucose probe

Related Targets

    Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.

    Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.

    External sources of pharmacological information for Glucose Transporters :

      Literature for Glucose Transporters

      Tocris offers the following scientific literature for Glucose Transporters to showcase our products. We invite you to request* your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.

      Cancer Metabolism Research Product Guide

      Cancer Metabolism Research Product Guide

      This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

      Cancer Metabolism Poster

      Cancer Metabolism Poster

      This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

      Glucose Transporter Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      Solute carrier family 2 (facilitated glucose transporter), member 1
      (GLUT1)       		Human SLC2A1 NM_006516 P11166
      Mouse Slc2a1 NM_011400 P17809
      Rat Slc2a1 NM_138827 P11167
      Solute carrier family 2 (facilitated glucose transporter), member 2
      (GLUT2)       		Human SLC2A2 NM_000340 P11168
      Mouse Slc2a2 NM_031197 P14246
      Rat Slc2a2 NM_012879 P12336
      Solute carrier family 2 (facilitated glucose transporter), member 3
      (GLUT3)       		Human SLC2A3 NM_006931 P11169
      Mouse Slc2a3 NM_011401 P32037
      Rat Slc2a3 NM_017102 Q6P506
      Solute carrier family 2 (facilitated glucose transporter), member 4
      (GLUT4)       		Human SLC2A4 NM_001042 P14672
      Mouse Slc2a4 NM_009204 P14142
      Rat Slc2a4 NM_012751 P19357
      Solute carrier family 2 (facilitated glucose transporter), member 5
      (GLUT5)       		Human SLC2A5 NM_003039 P22732
      Mouse Slc2a5 NM_019741 Q9WV38
      Rat Slc2a5 NM_031741 P43427
      Solute carrier family 2 (facilitated glucose transporter), member 6
      (GLUT6)       		Human SCL2A6 NM_017585 Q9UGQ3
      Mouse Slc2a6 NM_172659 Q3UDF0
      Rat Slc2a6 NM_001106562 EDL93446
      Solute carrier family 2 (facilitated glucose transporter), member 7
      (GLUT7)       		Human SCL2A7 NM_207420 Q6PXP3
      Mouse Slc2a7 NM_001085529 B1ARZ3
      Rat Slc2a7 NM_001101020 A4ZYQ5
      Solute carrier family 2 (facilitated glucose transporter), member 8
      (GLUT8)       		Human SLC2A8 NM_014580 Q9NY64
      Mouse Slc2a8 NM_019488 Q9IJF3
      Rat Slc2a8 NM_053494 Q9JJZ1
      Solute carrier family 2 (facilitated glucose transporter), member 9
      (GLUT9)       		Human SCL2A9 NM_001001290 Q9NRM0
      Mouse Slc2a9 NM_001102414 Q3T9X0
      Rat - - -
      Solute carrier family 2 (facilitated glucose transporter), member 10
      (GLUT10)       		Human SLC2A10 NM_030777 O95528
      Mouse Slc2a10 NM_130451 Q8VHD6
      Rat Slc2a10 NM_001108963 EDL96452
      Solute carrier family 2 (facilitated glucose transporter), member 11
      (GLUT11)       		Human SLC2A11 NM_030807 Q9BYW1
      Mouse - - -
      Rat - - -
      Solute carrier family 2 (facilitated glucose transporter), member 12
      (GLUT12)       		Human SLC2A12 NM_145176 Q8TD20
      Mouse Slc2a12 NM_178934 Q8BFW9
      Rat Slc2a12 NM_001107451 EDL87731
      Solute carrier family 2 (facilitated glucose transporter), member 13
      (HMIT)       		Human SLC2A13 NM_052885 Q96QE2
      Mouse Slc2a13 NM_001033633 Q3UHK1
      Rat Slc2a13 NM_133611 Q921A2