Glucose transporters enable the movement of glucose, a hydrophilic molecule, across the cell membrane. Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis.
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Glucose Transporter Inhibitors |
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Cat. No. | Product Name / Activity |
6199 | BAY 876 |
Potent and selective GLUT1 inhibitor | |
6100 | Fasentin |
GLUT1/GLUT4 inhibitor; also Fas-sensitizer | |
4484 | STF 31 |
GLUT1 inhibitor; also NAMPT inhibitor | |
6143 | WZB 117 |
GLUT inhibitor | |
Other |
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Cat. No. | Product Name / Activity |
6065 | 2-NBDG |
Fluorescent glucose uptake indicator | |
7447 | SCOTfluor glucose probe 510 |
Fluorescent glucose probe |
Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.
Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.
Tocris offers the following scientific literature for Glucose Transporters to showcase our products. We invite you to request* your copy today!
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
Solute carrier family 2 (facilitated glucose transporter), member 1
(GLUT1) |
Human | SLC2A1 | NM_006516 | P11166 |
Mouse | Slc2a1 | NM_011400 | P17809 | |
Rat | Slc2a1 | NM_138827 | P11167 | |
Solute carrier family 2 (facilitated glucose transporter), member 2
(GLUT2) |
Human | SLC2A2 | NM_000340 | P11168 |
Mouse | Slc2a2 | NM_031197 | P14246 | |
Rat | Slc2a2 | NM_012879 | P12336 | |
Solute carrier family 2 (facilitated glucose transporter), member 3
(GLUT3) |
Human | SLC2A3 | NM_006931 | P11169 |
Mouse | Slc2a3 | NM_011401 | P32037 | |
Rat | Slc2a3 | NM_017102 | Q6P506 | |
Solute carrier family 2 (facilitated glucose transporter), member 4
(GLUT4) |
Human | SLC2A4 | NM_001042 | P14672 |
Mouse | Slc2a4 | NM_009204 | P14142 | |
Rat | Slc2a4 | NM_012751 | P19357 | |
Solute carrier family 2 (facilitated glucose transporter), member 5
(GLUT5) |
Human | SLC2A5 | NM_003039 | P22732 |
Mouse | Slc2a5 | NM_019741 | Q9WV38 | |
Rat | Slc2a5 | NM_031741 | P43427 | |
Solute carrier family 2 (facilitated glucose transporter), member 6
(GLUT6) |
Human | SCL2A6 | NM_017585 | Q9UGQ3 |
Mouse | Slc2a6 | NM_172659 | Q3UDF0 | |
Rat | Slc2a6 | NM_001106562 | EDL93446 | |
Solute carrier family 2 (facilitated glucose transporter), member 7
(GLUT7) |
Human | SCL2A7 | NM_207420 | Q6PXP3 |
Mouse | Slc2a7 | NM_001085529 | B1ARZ3 | |
Rat | Slc2a7 | NM_001101020 | A4ZYQ5 | |
Solute carrier family 2 (facilitated glucose transporter), member 8
(GLUT8) |
Human | SLC2A8 | NM_014580 | Q9NY64 |
Mouse | Slc2a8 | NM_019488 | Q9IJF3 | |
Rat | Slc2a8 | NM_053494 | Q9JJZ1 | |
Solute carrier family 2 (facilitated glucose transporter), member 9
(GLUT9) |
Human | SCL2A9 | NM_001001290 | Q9NRM0 |
Mouse | Slc2a9 | NM_001102414 | Q3T9X0 | |
Rat | - | - | - | |
Solute carrier family 2 (facilitated glucose transporter), member 10
(GLUT10) |
Human | SLC2A10 | NM_030777 | O95528 |
Mouse | Slc2a10 | NM_130451 | Q8VHD6 | |
Rat | Slc2a10 | NM_001108963 | EDL96452 | |
Solute carrier family 2 (facilitated glucose transporter), member 11
(GLUT11) |
Human | SLC2A11 | NM_030807 | Q9BYW1 |
Mouse | - | - | - | |
Rat | - | - | - | |
Solute carrier family 2 (facilitated glucose transporter), member 12
(GLUT12) |
Human | SLC2A12 | NM_145176 | Q8TD20 |
Mouse | Slc2a12 | NM_178934 | Q8BFW9 | |
Rat | Slc2a12 | NM_001107451 | EDL87731 | |
Solute carrier family 2 (facilitated glucose transporter), member 13
(HMIT) |
Human | SLC2A13 | NM_052885 | Q96QE2 |
Mouse | Slc2a13 | NM_001033633 | Q3UHK1 | |
Rat | Slc2a13 | NM_133611 | Q921A2 |