Glucose Transporters

Glucose transporters enable the movement of glucose, a hydrophilic molecule, across the cell membrane. Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis.

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Products
Background
Literature (1)
Gene Data

Glucose Transporter Inhibitors

Cat. No. Product Name / Activity
6199 BAY 876
Potent and selective GLUT1 inhibitor
6100 Fasentin
GLUT1/GLUT4 inhibitor; also Fas-sensitizer
4484 STF 31
GLUT1 inhibitor; also NAMPT inhibitor
6143 WZB 117
GLUT inhibitor

Other

Cat. No. Product Name / Activity
6065 2-NBDG
Fluorescent glucose uptake indicator
7447 SCOTfluor glucose probe 510
Fluorescent glucose probe

Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.

Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.

External sources of pharmacological information for Glucose Transporters :

    Literature for Glucose Transporters

    Tocris offers the following scientific literature for Glucose Transporters to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer Research Product Guide

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis

    Glucose Transporter Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Solute carrier family 2 (facilitated glucose transporter), member 1
    (GLUT1)
    Human SLC2A1 NM_006516 P11166
    Mouse Slc2a1 NM_011400 P17809
    Rat Slc2a1 NM_138827 P11167
    Solute carrier family 2 (facilitated glucose transporter), member 2
    (GLUT2)
    Human SLC2A2 NM_000340 P11168
    Mouse Slc2a2 NM_031197 P14246
    Rat Slc2a2 NM_012879 P12336
    Solute carrier family 2 (facilitated glucose transporter), member 3
    (GLUT3)
    Human SLC2A3 NM_006931 P11169
    Mouse Slc2a3 NM_011401 P32037
    Rat Slc2a3 NM_017102 Q6P506
    Solute carrier family 2 (facilitated glucose transporter), member 4
    (GLUT4)
    Human SLC2A4 NM_001042 P14672
    Mouse Slc2a4 NM_009204 P14142
    Rat Slc2a4 NM_012751 P19357
    Solute carrier family 2 (facilitated glucose transporter), member 5
    (GLUT5)
    Human SLC2A5 NM_003039 P22732
    Mouse Slc2a5 NM_019741 Q9WV38
    Rat Slc2a5 NM_031741 P43427
    Solute carrier family 2 (facilitated glucose transporter), member 6
    (GLUT6)
    Human SCL2A6 NM_017585 Q9UGQ3
    Mouse Slc2a6 NM_172659 Q3UDF0
    Rat Slc2a6 NM_001106562 EDL93446
    Solute carrier family 2 (facilitated glucose transporter), member 7
    (GLUT7)
    Human SCL2A7 NM_207420 Q6PXP3
    Mouse Slc2a7 NM_001085529 B1ARZ3
    Rat Slc2a7 NM_001101020 A4ZYQ5
    Solute carrier family 2 (facilitated glucose transporter), member 8
    (GLUT8)
    Human SLC2A8 NM_014580 Q9NY64
    Mouse Slc2a8 NM_019488 Q9IJF3
    Rat Slc2a8 NM_053494 Q9JJZ1
    Solute carrier family 2 (facilitated glucose transporter), member 9
    (GLUT9)
    Human SCL2A9 NM_001001290 Q9NRM0
    Mouse Slc2a9 NM_001102414 Q3T9X0
    Rat - - -
    Solute carrier family 2 (facilitated glucose transporter), member 10
    (GLUT10)
    Human SLC2A10 NM_030777 O95528
    Mouse Slc2a10 NM_130451 Q8VHD6
    Rat Slc2a10 NM_001108963 EDL96452
    Solute carrier family 2 (facilitated glucose transporter), member 11
    (GLUT11)
    Human SLC2A11 NM_030807 Q9BYW1
    Mouse - - -
    Rat - - -
    Solute carrier family 2 (facilitated glucose transporter), member 12
    (GLUT12)
    Human SLC2A12 NM_145176 Q8TD20
    Mouse Slc2a12 NM_178934 Q8BFW9
    Rat Slc2a12 NM_001107451 EDL87731
    Solute carrier family 2 (facilitated glucose transporter), member 13
    (HMIT)
    Human SLC2A13 NM_052885 Q96QE2
    Mouse Slc2a13 NM_001033633 Q3UHK1
    Rat Slc2a13 NM_133611 Q921A2