Glucose Transporters

Glucose transporters enable the movement of glucose, a hydrophilic molecule, across the cell membrane. Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
6100 Fasentin
GLUT1/GLUT4 inhibitor; also Fas-sensitizer
4484 STF 31
GLUT1 inhibitor; also NAMPT inhibitor
6143 WZB 117
GLUT inhibitor

Other

Cat No Product Name / Activity
5734 L-Dehydroascorbic acid
GLUT1 substrate; oxidized form of L-Ascorbic acid
5504 D-(+)-Glucose
Naturally occurring monosaccharide
3506 NVP DPP 728 dihydrochloride
DPP-IV inhibitor; augments GLUT2 levels

Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.

Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.

Literature for Glucose Transporters

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Glucose Transporter Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Solute carrier family 2 (facilitated glucose transporter), member 1
(GLUT1)
Human SLC2A1 NM_006516 P11166
Mouse Slc2a1 NM_011400 P17809
Rat Slc2a1 NM_138827 P11167
Solute carrier family 2 (facilitated glucose transporter), member 2
(GLUT2)
Human SLC2A2 NM_000340 P11168
Mouse Slc2a2 NM_031197 P14246
Rat Slc2a2 NM_012879 P12336
Solute carrier family 2 (facilitated glucose transporter), member 3
(GLUT3)
Human SLC2A3 NM_006931 P11169
Mouse Slc2a3 NM_011401 P32037
Rat Slc2a3 NM_017102 Q6P506
Solute carrier family 2 (facilitated glucose transporter), member 4
(GLUT4)
Human SLC2A4 NM_001042 P14672
Mouse Slc2a4 NM_009204 P14142
Rat Slc2a4 NM_012751 P19357
Solute carrier family 2 (facilitated glucose transporter), member 5
(GLUT5)
Human SLC2A5 NM_003039 P22732
Mouse Slc2a5 NM_019741 Q9WV38
Rat Slc2a5 NM_031741 P43427
Solute carrier family 2 (facilitated glucose transporter), member 6
(GLUT6)
Human SCL2A6 NM_017585 Q9UGQ3
Mouse Slc2a6 NM_172659 Q3UDF0
Rat Slc2a6 NM_001106562 EDL93446
Solute carrier family 2 (facilitated glucose transporter), member 7
(GLUT7)
Human SCL2A7 NM_207420 Q6PXP3
Mouse Slc2a7 NM_001085529 B1ARZ3
Rat Slc2a7 NM_001101020 A4ZYQ5
Solute carrier family 2 (facilitated glucose transporter), member 8
(GLUT8)
Human SLC2A8 NM_014580 Q9NY64
Mouse Slc2a8 NM_019488 Q9IJF3
Rat Slc2a8 NM_053494 Q9JJZ1
Solute carrier family 2 (facilitated glucose transporter), member 9
(GLUT9)
Human SCL2A9 NM_001001290 Q9NRM0
Mouse Slc2a9 NM_001102414 Q3T9X0
Rat - - -
Solute carrier family 2 (facilitated glucose transporter), member 10
(GLUT10)
Human SLC2A10 NM_030777 O95528
Mouse Slc2a10 NM_130451 Q8VHD6
Rat Slc2a10 NM_001108963 EDL96452
Solute carrier family 2 (facilitated glucose transporter), member 11
(GLUT11)
Human SLC2A11 NM_030807 Q9BYW1
Mouse - - -
Rat - - -
Solute carrier family 2 (facilitated glucose transporter), member 12
(GLUT12)
Human SLC2A12 NM_145176 Q8TD20
Mouse Slc2a12 NM_178934 Q8BFW9
Rat Slc2a12 NM_001107451 EDL87731
Solute carrier family 2 (facilitated glucose transporter), member 13
(HMIT)
Human SLC2A13 NM_052885 Q96QE2
Mouse Slc2a13 NM_001033633 Q3UHK1
Rat Slc2a13 NM_133611 Q921A2