HMG-CoA Reductase

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3776 Atorvastatin hemicalcium salt
Potent HMG-CoA reductase inhibitor
3309 Fluvastatin sodium
Potent HMG-CoA reductase inhibitor
1530 Lovastatin
Potent HMG-CoA reductase inhibitor
1526 Mevastatin
HMG-CoA reductase inhibitor
4942 Pitavastatin calcium
HMG-CoA reductase inhibitor
2318 Pravastatin sodium salt
HMG-CoA reductase inhibitor
1965 Simvastatin
HMG-CoA reductase inhibitor

Other

Cat No Product Name / Activity
2969 SR 12813
Enhances HMG-CoA reductase degradation. Also PXR agonist

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed.

When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser872 phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.

Literature for HMG-CoA Reductase

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

HMG-CoA Reductase Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HMGCR NM_000859 P04035
Mouse Hmgcr NM_008255 Q01237
Rat Hmgcr NM_013134 P51639