HMG-CoA Reductase

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Products

Background

Literature

Gene Data

Inhibitors
Cat No	Product Name / Activity
3776	Atorvastatin hemicalcium salt
	Potent HMG-CoA reductase inhibitor
3309	Fluvastatin sodium
	Potent HMG-CoA reductase inhibitor
1530	Lovastatin
	Potent HMG-CoA reductase inhibitor
1526	Mevastatin
	HMG-CoA reductase inhibitor
4942	Pitavastatin calcium
	HMG-CoA reductase inhibitor
2318	Pravastatin sodium salt
	HMG-CoA reductase inhibitor
6343	Rosuvastatin calcium
	Potent HMG-CoA reductase inhibitor
1965	Simvastatin
	HMG-CoA reductase inhibitor
Other
Cat No	Product Name / Activity
2969	SR 12813
	Enhances HMG-CoA reductase degradation. Also PXR agonist

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed.

When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser⁸⁷² phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.

External sources of pharmacological information for HMG-CoA Reductase :

BJP Guide

Literature for HMG-CoA Reductase

Tocris offers the following scientific literature for HMG-CoA Reductase to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

Hypertension
Thrombosis and Hemostasis
Atherosclerosis
Myocardial Infarction
Ischemia/Reperfusion Injury
Arrhythmias
Heart Failure

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.