HMG-CoA Reductase
3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 3776 | Atorvastatin hemicalcium salt |
| Potent HMG-CoA reductase inhibitor | |
| 3309 | Fluvastatin sodium |
| Potent HMG-CoA reductase inhibitor | |
| 1530 | Lovastatin |
| Potent HMG-CoA reductase inhibitor | |
| 1526 | Mevastatin |
| HMG-CoA reductase inhibitor | |
| 4942 | Pitavastatin calcium |
| HMG-CoA reductase inhibitor | |
| 2318 | Pravastatin sodium salt |
| HMG-CoA reductase inhibitor | |
| 1965 | Simvastatin |
| HMG-CoA reductase inhibitor | |
Other |
|
| Cat No | Product Name / Activity |
| 2969 | SR 12813 |
| Enhances HMG-CoA reductase degradation. Also PXR agonist | |
3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed.
When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser872 phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.
Literature for HMG-CoA Reductase
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Apoptosis
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
Our New Product guide highlights over 130 new products added in the first half of 2017.
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