HMG-CoA Reductase

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Literature (3)
Gene Data

HMG-CoA Reductase Inhibitors

Cat. No. Product Name / Activity
3309 Fluvastatin sodium
Potent HMG-CoA reductase inhibitor
1530 Lovastatin
Potent HMG-CoA reductase inhibitor
1526 Mevastatin
HMG-CoA reductase inhibitor
4942 Pitavastatin calcium
HMG-CoA reductase inhibitor
2318 Pravastatin sodium salt
HMG-CoA reductase inhibitor
6343 Rosuvastatin calcium
Potent HMG-CoA reductase inhibitor
1965 Simvastatin
HMG-CoA reductase inhibitor


Cat. No. Product Name / Activity
2969 SR 12813
Enhances HMG-CoA reductase degradation. Also PXR agonist

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed.

When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser872 phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.

External sources of pharmacological information for HMG-CoA Reductase :

    Literature for HMG-CoA Reductase

    Tocris offers the following scientific literature for HMG-CoA Reductase to showcase our products. We invite you to request* your copy today!

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    HMG-CoA Reductase Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human HMGCR NM_000859 P04035
    Mouse Hmgcr NM_008255 Q01237
    Rat Hmgcr NM_013134 P51639