HMG-CoA Reductase

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Products

Background

Literature (3)

Gene Data

Inhibitors
Cat. No.	Product Name / Activity
3309	Fluvastatin sodium
	Potent HMG-CoA reductase inhibitor
1530	Lovastatin
	Potent HMG-CoA reductase inhibitor
1526	Mevastatin
	HMG-CoA reductase inhibitor
4942	Pitavastatin calcium
	HMG-CoA reductase inhibitor
2318	Pravastatin sodium salt
	HMG-CoA reductase inhibitor
6343	Rosuvastatin calcium
	Potent HMG-CoA reductase inhibitor
1965	Simvastatin
	HMG-CoA reductase inhibitor
Other
Cat. No.	Product Name / Activity
2969	SR 12813
	Enhances HMG-CoA reductase degradation. Also PXR agonist

3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed.

When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser⁸⁷² phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.

External sources of pharmacological information for HMG-CoA Reductase :

BJP Guide

Literature for HMG-CoA Reductase

Tocris offers the following scientific literature for HMG-CoA Reductase to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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