Modulators |
Cat. No. | Product Name / Activity |
---|---|
5796 | Azoramide |
Unfolded protein response (UPR) modulator | |
Inhibitors |
Cat. No. | Product Name / Activity |
5141 | AZD 5582 dihydrochloride |
Dimeric Smac mimetic; potent IAP inhibitor | |
4417 | DBeQ |
Selective and reversible p97 ATPase inhibitor | |
3922 | Eeyarestatin I |
Potent inhibitor of ER-associated protein degradation and translocation | |
5284 | trans-ISRIB |
Integrated stress response (ISR) inhibitor | |
5153 | ML 240 |
ATP-competitive inhibitor of p97 ATPase | |
6180 | NMS 873 |
Potent and selective p97 ATPase (VCP) allosteric inhibitor | |
2347 | Salubrinal |
Selective inhibitor of eIF2a dephosphorylation | |
4825 | TC ASK 10 |
Potent and selective ASK1 inhibitor; orally bioavailable | |
4686 | Xanthohumol |
p97 ATPase (VCP) inhibitor | |
Activators |
Cat. No. | Product Name / Activity |
5869 | CDN 1163 |
SERCA2 allosteric activator | |
7192 | SMIP 004 New |
S-phase kinase-associated protein 2 (SKP2) inhibitor; activates UPR | |
Other |
Cat. No. | Product Name / Activity |
6759 | AA 147 |
ER proteostasis regulator | |
1072 | AGN 192403 hydrochloride |
Binds TMED9 cargo receptor; releases mutant MUC-1 from vesicles and promotes trafficking to lysosome fro degradation | |
6116 | BHPI |
Activates unfolded protein response; also ERα antagonist | |
5375 | BIX |
BiP (Hsp70-5) ER chaperone inducer |