Other ER Stress/UPR
Other ER Stress/UPR Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5141 | AZD 5582 dihydrochloride |
| Dimeric Smac mimetic; potent IAP inhibitor | |
| 6955 | Ceapin A7 |
| Selective inhibitor of ATF6α; sensitizes cells to ER stress | |
| 3922 | Eeyarestatin I |
| Potent inhibitor of ER-associated protein degradation and translocation | |
| 5284 | trans-ISRIB |
| Integrated stress response (ISR) inhibitor | |
| 5153 | ML 240 |
| ATP-competitive inhibitor of p97 ATPase | |
| 6180 | NMS 873 |
| Potent and selective p97 ATPase (VCP) allosteric inhibitor | |
| 2347 | Salubrinal |
| Selective inhibitor of eIF2a dephosphorylation | |
| 4825 | TC ASK 10 |
| Potent and selective ASK1 inhibitor; orally bioavailable | |
Substrates |
|
| Cat. No. | Product Name / Activity |
| 4515 | 2-Deoxy-D-glucose |
| Enhances chimeric antigen receptor T cell activity. Disrupts N-glycan expression | |
Other ER Stress/UPR Activators |
|
| Cat. No. | Product Name / Activity |
| 1231 | Brefeldin A |
| Disrupts Golgi apparatus resulting in activation of ER stress pathways | |
| 5869 | CDN 1163 |
| SERCA2 allosteric activator | |
| 7192 | SMIP 004 |
| S-phase kinase-associated protein 2 (SKP2) inhibitor; activates UPR | |
Other |
|
| Cat. No. | Product Name / Activity |
| 6759 | AA 147 |
| ER proteostasis regulator | |
| 1072 | AGN 192403 hydrochloride |
| Binds TMED9 cargo receptor; releases mutant MUC-1 from vesicles and promotes trafficking to lysosome fro degradation | |
| 6116 | BHPI |
| Activates unfolded protein response; also ERα antagonist | |