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Biological Activity for Ceapin A7
Ceapin A7 is a selective inhibitor of ATF6α (IC50=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.
Technical Data for Ceapin A7
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ceapin A7
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ceapin A7
The following data is based on the product molecular weight 470.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.13 mL||10.63 mL||21.26 mL|
|5 mM||0.43 mL||2.13 mL||4.25 mL|
|10 mM||0.21 mL||1.06 mL||2.13 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References for Ceapin A7
References are publications that support the biological activity of the product.
Gallagher et al (2016) Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. eLife PMID: 27435960
Gallagher and Walter (2016) Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. eLife PMID: 27435962
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Citations for Ceapin A7
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