Salubrinal

Pricing Availability Delivery Time Qty
Cat.No. 2347 - Salubrinal | C21H17N4OSCl3 | CAS No. 405060-95-9
Description: Selective inhibitor of eIF2α dephosphorylation
Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews
Literature

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Compound Libraries

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Technical Data

M. Wt 479.81
Formula C21H17N4OSCl3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 405060-95-9
PubChem ID 5717801
InChI Key LCOIAYJMPKXARU-VAWYXSNFSA-N
Smiles S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935 PMID: 15705855

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849 PMID: 16002288


If you know of a relevant reference for Salubrinal, please let us know.

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View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Salubrinal, Salubrinal supplier, Selective, inhibitors, inhibits, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, ER, stress, Protein, Ser/Thr, Phosphatases, Other, stress/UPR, 2347, Tocris Bioscience

10 Citations for Salubrinal

Citations are publications that use Tocris products. Selected citations for Salubrinal include:

Shim et al (2013) Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor β in cartilage and chondrocytes. Hepatol Int 13 372 PMID: 23989259

Wan et al (2014) Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One 9 e105699 PMID: 25157407

Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796 PMID: 25279668

Hamamura et al (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. J Musculoskelet Neuronal Interact 4 84 PMID: 25977571

Vandewynckel et al (2015) Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy. PLoS One 9 93 PMID: 25598862

Gandin et al (2016) mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun 7 11127 PMID: 27040916

Konrad et al (2013) Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother 57 1815 PMID: 23380722

Hahn and Lowrey (2013) Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood 122 477 PMID: 23690448

Bergeron et al (2011) Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. J Biol Chem 286 11242 PMID: 21257749

Bennett et al (2011) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis 1 e72 PMID: 21364676


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