Pricing Availability   Qty
Description: Selective inhibitor of eIF2α dephosphorylation
Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity: ≥99% (HPLC)
Citations (11)

Biological Activity for Salubrinal

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Compound Libraries for Salubrinal

Salubrinal is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Salubrinal

M. Wt 479.81
Formula C21H17N4OSCl3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 405060-95-9
PubChem ID 5717801
Smiles S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Salubrinal

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.98 100

Preparing Stock Solutions for Salubrinal

The following data is based on the product molecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Salubrinal

References are publications that support the biological activity of the product.

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935 PMID: 15705855

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849 PMID: 16002288

If you know of a relevant reference for Salubrinal, please let us know.

View Related Products by Product Action

View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Salubrinal, Salubrinal supplier, Selective, inhibitors, inhibits, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, ER, stress, Protein, Ser/Thr, Phosphatases, Other, stress/UPR, Protein-synthesizing, GTPases, 2347, Tocris Bioscience

11 Citations for Salubrinal

Citations are publications that use Tocris products. Selected citations for Salubrinal include:

Hamamura et al (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. J Musculoskelet Neuronal Interact 4 84 PMID: 25977571

Vandewynckel et al (2015) Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy. PLoS One 9 93 PMID: 25598862

Konrad et al (2013) Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother 57 1815 PMID: 23380722

Hahn and Lowrey (2013) Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood 122 477 PMID: 23690448

Do you know of a great paper that uses Salubrinal from Tocris? Please let us know.

Reviews for Salubrinal

There are currently no reviews for this product. Be the first to review Salubrinal and earn rewards!

Have you used Salubrinal?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review