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Description: Selective inhibitor of eIF2α dephosphorylation
Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity: ≥99% (HPLC)
Citations (11)
Literature (1)

Biological Activity for Salubrinal

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Compound Libraries for Salubrinal

Salubrinal is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Salubrinal

M. Wt 479.81
Formula C21H17N4OSCl3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 405060-95-9
PubChem ID 5717801
Smiles S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Salubrinal

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.98 100

Preparing Stock Solutions for Salubrinal

The following data is based on the product molecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for Salubrinal

References are publications that support the biological activity of the product.

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935 PMID: 15705855

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849 PMID: 16002288

If you know of a relevant reference for Salubrinal, please let us know.

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View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Salubrinal, Salubrinal supplier, Selective, inhibitors, inhibits, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, ER, stress, Protein, Ser/Thr, Phosphatases, Other, stress/UPR, Protein-synthesizing, GTPases, 2347, Tocris Bioscience

11 Citations for Salubrinal

Citations are publications that use Tocris products. Selected citations for Salubrinal include:

Gandin et al (2016) mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun 7 11127 PMID: 27040916

Konrad et al (2013) Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother 57 1815 PMID: 23380722

Hahn and Lowrey (2013) Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood 122 477 PMID: 23690448

Hamamura et al (2015) Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis. J Musculoskelet Neuronal Interact 4 84 PMID: 25977571

Do you know of a great paper that uses Salubrinal from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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