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Description: ERα antagonist; also activates unfolded protein response; active in vivo
Chemical Name: 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for BHPI

BHPI is an estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.

Compound Libraries for BHPI

BHPI is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BHPI

M. Wt 331.36
Formula C21H17NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 56632-39-4
PubChem ID 3860640
Smiles CC1=CC=CC2=C1NC(C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BHPI

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.14 100
ethanol 33.14 100

Preparing Stock Solutions for BHPI

The following data is based on the product molecular weight 331.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for BHPI

References are publications that support the biological activity of the product.

Andruska et al (2015) Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc.Natl.Acad.Sci.U.S.A. 112 4737 PMID: 25825714

If you know of a relevant reference for BHPI, please let us know.

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Keywords: BHPI, BHPI supplier, estrogen, receptor, alpha, ER, α, inhibitor, UPR, unfolded, protein, response, Estrogen, (GPER), Receptors, Other, stress/UPR, 6116, Tocris Bioscience

Citations for BHPI

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Pathways for BHPI

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.