BHPI

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Cat.No. 6116 - BHPI | C21H17NO3 | CAS No. 56632-39-4
Description: ERα antagonist; also activates unfolded protein response; active in vivo
Chemical Name: 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.

Technical Data

M. Wt 331.36
Formula C21H17NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 56632-39-4
PubChem ID 3860640
InChI Key FABLAHMQSQFDHR-UHFFFAOYSA-N
Smiles CC1=CC=CC2=C1NC(C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.14 100
ethanol 33.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Andruska et al (2015) Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc.Natl.Acad.Sci.U.S.A. 112 4737 PMID: 25825714


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Keywords: BHPI, supplier, estrogen, receptor, alpha, ER, α, inhibitor, UPR, unfolded, protein, response, Estrogen, (GPER), Receptors, Other, ER, stress/UPR, Estrogen, (GPER), Receptors, Tocris Bioscience

Citations for BHPI

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for BHPI

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.