AGN 192403 hydrochloride

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Description: I1 selective ligand
Alternative Names: BRD4780
Chemical Name: (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Citations (2)

Biological Activity for AGN 192403 hydrochloride

AGN 192403 hydrochloride is an i1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Causes none of the physiological responses associated with the I1 binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Technical Data for AGN 192403 hydrochloride

M. Wt 189.73
Formula C10H19N.HCl
Storage Store at RT
CAS Number 1021868-90-5
PubChem ID 11957452
Smiles Cl.CC(C)C1C(C2CC1CC2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AGN 192403 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for AGN 192403 hydrochloride

The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.35 mL 52.71 mL
5 mM 1.05 mL 5.27 mL 10.54 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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Product Datasheets for AGN 192403 hydrochloride

Certificate of Analysis / Product Datasheet
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References for AGN 192403 hydrochloride

References are publications that support the biological activity of the product.

Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73 PMID: 16774751

Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193 PMID: 8632424

Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663 PMID: 11834614

Dvela-Levitt (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885

If you know of a relevant reference for AGN 192403 hydrochloride, please let us know.

Keywords: AGN 192403 hydrochloride, AGN 192403 hydrochloride supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, mutant, MUC1, mucin-1, TMED9, proteinopathy, BRD4780, Other, ER, stress/UPR, 1072, Tocris Bioscience

2 Citations for AGN 192403 hydrochloride

Citations are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:

Dvela-Levitt et al (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010

Do you know of a great paper that uses AGN 192403 hydrochloride from Tocris? Please let us know.

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