AGN 192403 hydrochloride

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Cat.No. 1072 - AGN 192403 hydrochloride | C10H19N.HCl | CAS No. 1021868-90-5
Description: I1 selective ligand
Alternative Names: BRD4780
Chemical Name: (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Causes none of the physiological responses associated with the I1 binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Technical Data

M. Wt 189.73
Formula C10H19N.HCl
Storage Store at RT
CAS Number 1021868-90-5
PubChem ID 11957452
InChI Key KSTGYMXUFHCTSM-UHFFFAOYSA-N
Smiles Cl.CC(C)C1C(C2CC1CC2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73 PMID: 16774751

Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193 PMID: 8632424

Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663 PMID: 11834614

Dvela-Levitt (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885


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Keywords: AGN 192403 hydrochloride, AGN 192403 hydrochloride supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, mutant, MUC1, mucin-1, TMED9, proteinopathy, BRD4780, Other, ER, stress/UPR, 1072, Tocris Bioscience

2 Citations for AGN 192403 hydrochloride

Citations are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:

Dvela-Levitt et al (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010


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Literature in this Area

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