AGN 192403 hydrochloride
I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Interestingly, in animal models, this compound causes none of the physiological responses associated with the I1 binding site.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.27 mL||26.35 mL||52.71 mL|
|5 mM||1.05 mL||5.27 mL||10.54 mL|
|10 mM||0.53 mL||2.64 mL||5.27 mL|
|50 mM||0.11 mL||0.53 mL||1.05 mL|
References are publications that support the products' biological activity.
Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73 PMID: 16774751
Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193 PMID: 8632424
Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663 PMID: 11834614
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Keywords: AGN 192403 hydrochloride, supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, I1, Receptors, I1, Receptors, Tocris Bioscience
1 Citation for AGN 192403 hydrochloride
Citations are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:
Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010
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