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AGN 192403 hydrochloride is an i1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Causes none of the physiological responses associated with the I1 binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.27 mL||26.35 mL||52.71 mL|
|5 mM||1.05 mL||5.27 mL||10.54 mL|
|10 mM||0.53 mL||2.64 mL||5.27 mL|
|50 mM||0.11 mL||0.53 mL||1.05 mL|
References are publications that support the biological activity of the product.
Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73 PMID: 16774751
Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J.Med.Chem. 39 1193 PMID: 8632424
Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663 PMID: 11834614
Dvela-Levitt (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885
If you know of a relevant reference for AGN 192403 hydrochloride, please let us know.
Keywords: AGN 192403 hydrochloride, AGN 192403 hydrochloride supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, mutant, MUC1, mucin-1, TMED9, proteinopathy, BRD4780, Other, ER, stress/UPR, 1072, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for AGN 192403 hydrochloride include:
Dvela-Levitt et al (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885
Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010
Do you know of a great paper that uses AGN 192403 hydrochloride from Tocris? Please let us know.
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