Pricing Availability   Qty
Description: Potent and selective ASK1 inhibitor; orally bioavailable
Chemical Name: 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for TC ASK 10

TC ASK 10 is a potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC50 values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

Compound Libraries for TC ASK 10

TC ASK 10 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TC ASK 10

M. Wt 432.35
Formula C21H21N5O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1005775-56-3
PubChem ID 68661090
Smiles O=C(C4=CC=C(C(C)(C)C)C=C4)NC1=CN2C(C=CC(N3C=NC=C3)=C2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC ASK 10

Solvent Max Conc. mg/mL Max Conc. mM
water 43.23 100
DMSO 43.23 100

Preparing Stock Solutions for TC ASK 10

The following data is based on the product molecular weight 432.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for TC ASK 10

Certificate of Analysis / Product Datasheet
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References for TC ASK 10

References are publications that support the biological activity of the product.

Terao et al (2012) Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg.Med.Chem.Lett. 22 7326 PMID: 23147077

If you know of a relevant reference for TC ASK 10, please let us know.

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Keywords: TC ASK 10, TC ASK 10 supplier, TCASK10, apoptosis, signal, regulating, kinase, ASK1, potent, selective, inhibitors, inhibits, cell, permeable, active, orally, bioavailable, Other, ER, stress/UPR, 4825, Tocris Bioscience

Citations for TC ASK 10

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