2-Deoxy-D-glucose

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Cat.No. 4515 - 2-Deoxy-D-glucose | C6H12O5 | CAS No. 154-17-6
Description: Non-metabolizable glucose analog; hexokinase substrate
Chemical Name: 2-Deoxy-D-arabino-hexose
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Technical Data

M. Wt 164.16
Formula C6H12O5
Storage Store at +4°C
CAS Number 154-17-6
PubChem ID 439268
InChI Key PMMURAAUARKVCB-CERMHHMHSA-N
Smiles OC1C[C@@H](O)[C@H](O)[C@@H](CO)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.42 100
DMSO 16.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 164.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.46 mL 60.92 mL
5 mM 1.22 mL 6.09 mL 12.18 mL
10 mM 0.61 mL 3.05 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392 PMID: 16111712

Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116 PMID: 14605866

Ralser et al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 105 17807


If you know of a relevant reference for 2-Deoxy-D-glucose, please let us know.

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View all Hexokinases Substrates

Keywords: 2-Deoxy-D-glucose, 2-Deoxy-D-glucose supplier, non-metabolizable, hexokinase, substrates, hypoxia, hypoxic, cell, growth, inhibitors, inhibits, inhibition, Hexokinases, Enzyme, Substrates, /, Activators, 4515, Tocris Bioscience

1 Citation for 2-Deoxy-D-glucose

Citations are publications that use Tocris products. Selected citations for 2-Deoxy-D-glucose include:

Lin et al (2017) Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget 8 110426 PMID: 29299159


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Reviews for 2-Deoxy-D-glucose

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Glycolysis block.
By Anonymous on 01/31/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: acute brain slice

Used in brain slices to block glycolysis. Effect observed on cells within minutes of bulk application, as expected.


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