2-Deoxy-D-glucose

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Cat.No. 4515 - 2-Deoxy-D-glucose | C6H12O5 | CAS No. 154-17-6
Description: Non-metabolizable glucose analog; hexokinase substrate
Chemical Name: 2-Deoxy-D-arabino-hexose
Datasheet
Citations
Literature

Biological Activity

Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Technical Data

M. Wt 164.16
Formula C6H12O5
Storage Store at +4°C
CAS Number 154-17-6
PubChem ID 439268
InChI Key PMMURAAUARKVCB-CERMHHMHSA-N
Smiles OC1C[C@@H](O)[C@H](O)[C@@H](CO)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.42 100
water 16.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 164.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.46 mL 60.92 mL
5 mM 1.22 mL 6.09 mL 12.18 mL
10 mM 0.61 mL 3.05 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

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View all Hexokinases Substrates

Keywords: non-metabolizable hexokinase substrates hypoxia hypoxic cell growth inhibitors inhibits inhibition Hexokinases

Citations for 2-Deoxy-D-glucose

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Literature in this Area

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Pathways for 2-Deoxy-D-glucose

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