AA 147

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Description: ER proteostasis regulator
Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity: ≥98% (HPLC)
Citations (5)
Reviews (1)

Biological Activity for AA 147

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).

Compound Libraries for AA 147

AA 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AA 147

M. Wt 255.31
Formula C16H17NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 393121-74-9
PubChem ID 882909
Smiles CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AA 147

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.53 100
ethanol 25.53 100

Preparing Stock Solutions for AA 147

The following data is based on the product molecular weight 255.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.17 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References for AA 147

References are publications that support the biological activity of the product.

Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961

If you know of a relevant reference for AA 147, please let us know.

Keywords: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience

5 Citations for AA 147

Citations are publications that use Tocris products. Selected citations for AA 147 include:

Xiaoyan et al (2022) Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes. Nat Commun 13 5859 PMID: 36216837

Jochen H M et al (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun 14 2132 PMID: 37059720

Yang et al (2021) Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Front Surg 8 665260 PMID: 34222317

Shu et al (2021) Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. J Am Heart Assoc 10 e020216 PMID: 34111943

Do you know of a great paper that uses AA 147 from Tocris? Please let us know.

Reviews for AA 147

Average Rating: 5 (Based on 1 Review.)

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ATF6 activation.
By Anonymous on 10/30/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Molm13

Used to induce activation of the ATF6 ER stress pathway

Worked well, induced translocation of ATF to the nucleus (green in image), showing cleavage of the protein and its activation. Caused reduction of downstream inhibited genes CPT1a and PPARA in our experiments

review image