AA 147

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Cat.No. 6759 - AA 147 | C16H17NO2 | CAS No. 393121-74-9
Description: ER proteostasis regulator
Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).

Compound Libraries

AA 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 255.31
Formula C16H17NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 393121-74-9
PubChem ID 882909
Smiles CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.53 100
ethanol 25.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.17 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References are publications that support the biological activity of the product.

Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961

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Keywords: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience

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