You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 255.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.92 mL||19.58 mL||39.17 mL|
|5 mM||0.78 mL||3.92 mL||7.83 mL|
|10 mM||0.39 mL||1.96 mL||3.92 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the biological activity of the product.
Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961
If you know of a relevant reference for AA 147, please let us know.
Keywords: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience
Citations for AA 147
Citations are publications that use Tocris products.
Currently there are no citations for AA 147. Do you know of a great paper that uses AA 147 from Tocris? Please let us know.
Reviews for AA 147
There are currently no reviews for this product. Be the first to review AA 147 and earn rewards!
Have you used AA 147?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells