AA 147

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Description: ER proteostasis regulator
Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)

Biological Activity for AA 147

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).

Compound Libraries for AA 147

AA 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AA 147

M. Wt 255.31
Formula C16H17NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 393121-74-9
PubChem ID 882909
InChI Key AWHLTHOHBAGPMY-UHFFFAOYSA-N
Smiles CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AA 147

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.53 100
ethanol 25.53 100

Preparing Stock Solutions for AA 147

The following data is based on the product molecular weight 255.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.17 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for AA 147

References are publications that support the biological activity of the product.

Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961


If you know of a relevant reference for AA 147, please let us know.

Keywords: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience

Citations for AA 147

Citations are publications that use Tocris products.

Currently there are no citations for AA 147. Do you know of a great paper that uses AA 147 from Tocris? Please let us know.

Reviews for AA 147

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used AA 147?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


ATF6 activation.
By Anonymous on 10/30/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Molm13

Used to induce activation of the ATF6 ER stress pathway

Worked well, induced translocation of ATF to the nucleus (green in image), showing cleavage of the protein and its activation. Caused reduction of downstream inhibited genes CPT1a and PPARA in our experiments

review image