NO Donors / Precursors

Nitric Oxide (NO) is an important signaling molecule that is involved in both physiological and pathological processes. Nitric oxide donors and precursors, as the name suggests, provide a functional NO group that can be involved in nitric oxide signaling pathways.

Products
Background
Literature
Cat No Product Name / Activity
0722 N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Nitroxyl precursor
0663 L-Arginine
Endogenous substrate for NOS
6077 DETA NONOate
Nitric oxide donor
3105 FK 409
NO donor
4531 NCX 4040
NO-donating aspirin; anti-inflammatory and antitumor
4537 NCX 466
Cyclooxygenase-inhibiting nitric oxide donor
2147 Nicorandil
NO donor and KATP channel opener
0756 SIN-1 chloride
Water-soluble NO donor
0598 SNAP
A stable analog of endogenous S-nitroso compounds
0603 SNOG
NO carrier. Breaks down to release NO
1135 Spermine NONOate
Slow NO releasing agent

Nitric Oxide (NO) is an important signaling molecule that is involved in both physiological and pathological processes. Nitric oxide donors and precursors, as the name suggests, provide a functional NO group that can be involved in nitric oxide signaling pathways.

Nitric oxide is an autocrine and paracrine signaling molecule that can diffuse through biological membranes. It has a very short duration of action (a few seconds) and its main physiological function is to contribute to the homeostasis of the vasculature. Nitric oxide inhibits smooth muscle contraction and growth, inhibits platelet aggregation and prevents leukocyte-endothelial adhesion. Nitric oxide is also involved in immune defence; it is generated by phagocytes and destroys bacteria through its action as a free radical. Targets of nitric oxide include guanylyl cyclase, which increase cGMP levels and NF-κB, which acts as a transcription factor in iNOS gene expression.

Perturbations in nitric oxide levels and signaling has been shown to occur in some disease states. People with diabetes tend to have lower global levels of nitric oxide and atherosclerotic blood vessels have impaired nitric oxide signaling pathways.

Literature for NO Donors / Precursors

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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  • Angiogenesis
  • Invasion and Metastasis