A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 220.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.54 mL||22.7 mL||45.41 mL|
|5 mM||0.91 mL||4.54 mL||9.08 mL|
|10 mM||0.45 mL||2.27 mL||4.54 mL|
|50 mM||0.09 mL||0.45 mL||0.91 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitroglycerin and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249 PMID: 1899118
Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915 PMID: 7969812
Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23 PMID: 9336304
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
If you know of a relevant reference for SNAP, please let us know.
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Keywords: stable endogenous S-nitroso ROS Donors NO Precursors Nitric Oxide Signaling Signalling NO Donors / Precursors
6 Citations for SNAP
Citations are publications that use Tocris products. Selected citations for SNAP include:
Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife 6 e23786 PMID: 28402252
Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400
Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328 PMID: 21156174
Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept J Biol Chem 285 8743 PMID: 20042609
Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791
Nistri et al (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med 4 32 PMID: 12734571
Do you know of a great paper that uses SNAP from Tocris? If so please let us know.