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Description: A stable analog of endogenous S-nitroso compounds
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Citations (10)
Reviews (1)

Biological Activity for SNAP

SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.

Technical Data for SNAP

M. Wt 220.24
Formula C7H12N2O4S
Storage Store at -20°C
CAS Number 79032-48-7
PubChem ID 5231
Smiles O=NSC(C)(C)C(NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNAP

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.02 100

Preparing Stock Solutions for SNAP

The following data is based on the product molecular weight 220.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.54 mL 22.7 mL 45.41 mL
5 mM 0.91 mL 4.54 mL 9.08 mL
10 mM 0.45 mL 2.27 mL 4.54 mL
50 mM 0.09 mL 0.45 mL 0.91 mL

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Product Datasheets for SNAP

Certificate of Analysis / Product Datasheet
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References for SNAP

References are publications that support the biological activity of the product.

Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249 PMID: 1899118

Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915 PMID: 7969812

Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23 PMID: 9336304

Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570

If you know of a relevant reference for SNAP, please let us know.

Keywords: SNAP, SNAP supplier, stable, endogenous, S-nitroso, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0598, Tocris Bioscience

10 Citations for SNAP

Citations are publications that use Tocris products. Selected citations for SNAP include:

Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609

Nistri et al (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med 4 32 PMID: 12734571

Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119 590 PMID: 8894183

Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791

Do you know of a great paper that uses SNAP from Tocris? Please let us know.

Reviews for SNAP

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JNK-dependent rescue of LTPGABA by acute norBNI.
By Anonymous on 03/18/2020
Assay Type: In Vivo
Species: Rat
Cell Line/Tissue: brain

IPSCs used before and 15 min after drug application (SNAP, 400 µM)

PMID: 28402252
review image