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Description: A stable analog of endogenous S-nitroso compounds
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Citations (10)
Reviews (1)
Literature (1)

Biological Activity for SNAP

SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.

Technical Data for SNAP

M. Wt 220.24
Formula C7H12N2O4S
Storage Store at -20°C
CAS Number 79032-48-7
PubChem ID 5231
Smiles O=NSC(C)(C)C(NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNAP

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.02 100

Preparing Stock Solutions for SNAP

The following data is based on the product molecular weight 220.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.54 mL 22.7 mL 45.41 mL
5 mM 0.91 mL 4.54 mL 9.08 mL
10 mM 0.45 mL 2.27 mL 4.54 mL
50 mM 0.09 mL 0.45 mL 0.91 mL

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Product Datasheets for SNAP

Certificate of Analysis / Product Datasheet
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References for SNAP

References are publications that support the biological activity of the product.

Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249 PMID: 1899118

Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915 PMID: 7969812

Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23 PMID: 9336304

Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570

If you know of a relevant reference for SNAP, please let us know.

Keywords: SNAP, SNAP supplier, stable, endogenous, S-nitroso, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0598, Tocris Bioscience

10 Citations for SNAP

Citations are publications that use Tocris products. Selected citations for SNAP include:

Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791

Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843

Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife 6 e23786 PMID: 28402252

Sánchez et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171 5682 PMID: 25091502

Do you know of a great paper that uses SNAP from Tocris? Please let us know.

Reviews for SNAP

Average Rating: 5 (Based on 1 Review.)

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JNK-dependent rescue of LTPGABA by acute norBNI.
By Anonymous on 03/18/2020
Assay Type: In Vivo
Species: Rat
Cell Line/Tissue: brain

IPSCs used before and 15 min after drug application (SNAP, 400 µM)

PMID: 28402252
review image

Literature in this Area

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