Hedgehog Signaling Inhibitors

Cat. No. Product Name / Activity
1639 AY 9944 dihydrochloride
Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase
4838 AZ 12080282 dihydrochloride
Inhibitor of Hedgehog (Hh) signaling
4529 Ciliobrevin A
Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling
6896 Dynapyrazole A
Hedgehog signaling inhibitor; dynein inhibitor
6526 Dynarrestin
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
5695 Eggmanone
Suppresses hedgehog signaling downstream of smoothened; also PDE4 inhibitor
3889 GANT 58
GLI1 antagonist; inhibits Hedgehog (Hh) signaling
3191 GANT 61
GLI antagonist; inhibits Hedgehog (Hh) signaling
3839 HPI 1
Inhibits Hedgehog signaling
5554 IHR 1
Potent Smo antagonist
5561 IHR-Cy3
Potent fluorescent Smo antagonist
4717 Jervine
Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo
3341 JK 184
Downstream Hedgehog (Hh) signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
4917 M 25
Potent Smoothened (Smo) receptor antagonist
4585 MRT 10
Smoothened (Smo) antagonist
6538 PF 04449913 maleate
Potent Smo antagonist
5262 PF 5274857 hydrochloride
High affinity and selective Smoothened (Smo) receptor antagonist
4886 RU-SKI 43 hydrochloride
Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
1974 SANT-1
Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
3617 SANT-2
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
4662 SMANT hydrochloride
Inhibits Smoothened (Smo) accumulation
1638 U 18666A
Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis